Management of physiological gynaecomastia with tamoxifen

Is There a Rationale behind Pharmacotherapy in Idiopathic Gynecomastia?

“…Medical treatment can be beneficial if administered during the proliferative phase, before stromal hyalinization and fibrosis of the gland. The most commonly used drugs in treatment of gynecomastia are selective ER modulators – tamoxifen and raloxifene [22-24]. Lawrence et al [24] used a 3- to 9-month course of tamoxifen or raloxifene to treat 38 men with persistent pubertal gynecomastia and demonstrated a mean reduction in breast nodule diameter of 2.1 cm with no serious adverse effects in 86% of the patients receiving tamoxifen and in 91% of those receiving raloxifene.…”

Terapia médica de la ginecomastia con tamoxifeno. Influencia del volumen y duración de la ginecomastia en el resultado terapéutico

“…El tamoxifeno fue eficaz en la desaparición rápida del dolor, resultado concordante con la literatura [20][21][22][23] . Sólo en un paciente recidivó.…”

“…Los resultados de disminución de volumen concuerdan con la bibliografía [15][16][17][20][21][22][23][24] y difiere de otro 18 , en este último la escasa reducción de tamaño se debería a un breve período de terapia.…”

Childhood Gynecomastia: A Mini Review

“…In recent years, anti-estrogens such as tamoxifen and anastrozole has been shown to be effective. More studies are needed to assess the effectiveness of aromatose inhibitors such as anastrozle and testalactone, which are powerful agents that block estrogen [32,[38][39][40][41][42][43].…”