Management of Post-Liver Transplant Recurrence of Hepatitis C

Taylor, Justin; Cox-North, Paula

doi:10.1007/s40265-016-0658-0

Cited by 5 publications

(3 citation statements)

References 44 publications

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“…Recurrence of infection in the donor graft is essentially universal if HCV RNA is detectable in the recipient prior to LT. The course of HCV in the immunosuppressed transplant recipient is more aggressive than that in immunocompetent individuals, resulting in rapid development of fibrosis, with approximately 30% of patients developing cirrhosis within 5 years of transplantation 2,3…”

Section: Introductionmentioning

confidence: 99%

Transplantation of HCV Viremic Livers into HCV Viremic Recipients Followed by Direct-acting Antiviral Therapy

Kapila

Khalloufi

Flocco

et al. 2019

Journal of Clinical and Translational Hepatology

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Background and Aims: Hepatitis C virus (HCV)-infected organs are underutilized. We aimed to assess the safety and efficacy of direct-acting antiviral agents (DAAs) therapy in HCV viremic patients who are transplanted with a liver from a HCV viremic donor. Methods: We conducted a retrospective study, including patients seen from July 2015 to April 2017. HCV viremic patients transplanted with a liver from a HCV viremic donor and subsequently treated with DAAs were included. Outcomes assessed included undetectable viral load at 12 weeks after completing DAA therapy (sustained virologic response, SVR 12 ), adverse events, and interactions with immunosuppression. Results: Twenty-four HCV viremic recipients received livers from HCV viremic donors. Median age was 63 years, and the majority (79.2%) were genotype 1a. Donors and recipients were viremic at the time of transplant. Median modified model for end-stage liver disease score was 19, and median time on the waitlist was 81 days. Median time from transplant to initiation of DAA therapy was 123 days. Several DAA regimens were used and 15 (62.5%) patients did not receive ribavirin. Treatment duration ranged from 12 to 24 weeks. Twenty-three (95.8%) patients achieved SVR 12 . Five (20.8%) patients developed adverse events; however, none required DAA discontinuation. Conclusions: DAA therapy was efficacious and well tolerated in HCV viremic recipients who underwent liver transplantation from a HCV viremic donor.

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Section: Introductionmentioning

confidence: 99%

Transplantation of HCV Viremic Livers into HCV Viremic Recipients Followed by Direct-acting Antiviral Therapy

Kapila

Khalloufi

Flocco

et al. 2019

Journal of Clinical and Translational Hepatology

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“…Both glycogen phosphorylase and glycogen synthase are part of a proteinglycogen complex in skeletal muscle and are recovered in a glycogen pellet fraction prepared from this tissue (138,139). Table 11 shows thac heart cell glycogen phosphorylase and glycogen synthase are also recovered in a glycogen pellet fraction.…”

Section: Desensitization Of the Beta-adrenergic Responsementioning

confidence: 99%

Studies of adrenergic hormone action and protein thiolation in beating rat heart cells

Fisher

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“…^p <0.01 compared to appropriate control. (138,139). Table 11 shows thac heart cell glycogen phosphorylase and glycogen synthase are also recovered in a glycogen pellet fraction.…”

Section: 14mentioning

confidence: 99%

Studies of adrenergic hormone action and protein thiolation in beating rat heart cells

Fisher

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Management of Post-Liver Transplant Recurrence of Hepatitis C

Cited by 5 publications

References 44 publications

Transplantation of HCV Viremic Livers into HCV Viremic Recipients Followed by Direct-acting Antiviral Therapy

Transplantation of HCV Viremic Livers into HCV Viremic Recipients Followed by Direct-acting Antiviral Therapy

Studies of adrenergic hormone action and protein thiolation in beating rat heart cells

Studies of adrenergic hormone action and protein thiolation in beating rat heart cells

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