Management of postpartum thyrotoxicosis

Azizi, Fereidoun; Braverman, Lewis E.

doi:10.1097/01.med.0000184297.22693.2e

Cited by 3 publications

(3 citation statements)

References 47 publications

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“…Increased thyroidal uptake, high T3:T4 ratio, positive TSH-receptor antibody results could differentiate Graves' disease from postpartum thyroiditis. The patient's thyrotoxic phase of postpartum thyroiditis lasts few weeks and does not require treatment [92]. Postpartum thyrotoxicosis due to Graves' disease may be treated with radioiodine, but is contraindicated if the mother is breastfeeding.…”

Section: Postpartum Periodmentioning

confidence: 97%

“…Because there is an exacerbation of thyrotoxicosis after delivery [113], it is recommended that thionamide drugs be continued throughout pregnancy and postpartum periods. In recent years, the controversy about treatment of lactating mothers with thionamide agents had been resolved and they can be safely administered to lactating hyperthyroid mothers [92,96]. Clinicians should carefully observe the diagnosis, treatment, and follow-up patients with hyperthyroidism in the pregnancy and postpartum periods.…”

Section: Expert Opinionmentioning

confidence: 98%

“…The timely and accurate diagnosis and management are important and improve the quality of life of mothers, fetuses and infants. Thionamide medications remain the mainstay of treatment of hyperthyroidism during pregnancy and the postpartum and lactation periods [92]. …”

Section: Expert Opinionmentioning

confidence: 99%

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The safety and efficacy of antithyroid drugs

Azizi

2005

Expert Opinion on Drug Safety

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Thionamides, selective inhibitors of thyroid peroxidase-mediated iodination by tyrosine residues in thyroglobulin, have been effectively used in the treatment of hyperthyroidism. The choices for initial treatment of patients with Graves' disease differ in various countries, and many physicians around the world prefer to administer thionamide drugs as the first choice of treatment for patients with hyperthyroidism. Although some thyroidologists more often consider radioiodine to be the treatment of choice because of its safety and ease of administration, thionamides remain the mainstay of treatment in thyrotoxic children and adolescents and in hyperthyroid women during pregnancy, postpartum period and lactation. A recent study with continuous thionamide treatment for patients with Graves' disease shows its efficacy, safety and cost-benefit properties. Further studies of the effectiveness of continuous thionamide therapy in patients with thyrotoxicosis need to be designed and implemented to determine indications for such therapy in children, adolescents and adults with diffuse toxic goiter, in particular, in those who have had recurrence of hyperthyroidism after discontinuation of one complete course of treatment.

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Section: Postpartum Periodmentioning

confidence: 97%

Section: Expert Opinionmentioning

confidence: 98%

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The safety and efficacy of antithyroid drugs

Azizi

2005

Expert Opinion on Drug Safety

Self Cite

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Postpartum Thyrotoxicosis

Azizi

2022

Thyroid Diseases in Pregnancy

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Thyroid disorders in pregnancy

Rajput

Bajaj

Ghosh

et al. 2021

Thyroid Research and Practice

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Thyroid disease is the second most common endocrine disorder encountered in pregnant women with substantial maternal and fetal implications. Therefore, assessing thyroid status during pregnancy is essential for initiating treatment in newly diagnosed individuals and adjusting doses for those already under treatment. To initiate proper and timely treatment evidence-based recommendations are required for clinical decisionmaking in managing thyroid disorders in pregnant and postpartum women. Keeping this in mind, task force consisted of experts in the fields of endocrinology and thyroid disease was constituted and various published data and guidelines were explored to address screening, diagnosis, and management of hypothyroidism, thyrotoxicosis, GD, thyroid nodules, and post-partum thyroiditis and their related complications during pregnancy. This document provides much-required insights and useful, practical, and accurate guidance that aids a practicing clinician.

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Management of postpartum thyrotoxicosis

Cited by 3 publications

References 47 publications

The safety and efficacy of antithyroid drugs

The safety and efficacy of antithyroid drugs

Postpartum Thyrotoxicosis

Thyroid disorders in pregnancy

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