Management of Pre-eclampsia and Eclampsia: A Simulation

Abraham, Cynthia; Kusheleva, N.

doi:10.15766/mep_2374-8265.10832

Cited by 17 publications

(10 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…It is well established that in-person simulation increases provider readiness and knowledge ( 23 – 32 ). Additionally, studies have provided evidence that the benefits of in-person simulation courses are comparable among active in-person participants versus passive in-person observers ( 33 – 36 ).…”

Section: Discussionmentioning

confidence: 99%

Comparison of In-Person and Telesimulation for Critical Care Training during the COVID-19 Pandemic

2021

View full text Add to dashboard Cite

Background The coronavirus disease (COVID-19) pandemic has disrupted medical education for trainees of all levels. Although telesimulation was initially used to train in resource-limited environments, it may be a reasonable alternative for replicating authentic patient experiences for medical students during the COVID-19 pandemic. It is unclear whether a more passive approach through telesimulation training is as effective as traditional in-person simulation training. Objective Our aim was to evaluate the effectiveness of in-person versus remote simulation training on learners’ comfort with managing critical care scenarios. Methods This was a prospective observational cohort study assessing the impact of an in-person versus remote simulation course on volunteer fourth-year medical students from February to April 2021 at the University of California San Diego School of Medicine. Precourse and postcourse surveys were performed anonymously using an online secure resource. Results In the in-person learners, there was statistically significant improvement in learner comfort across all technical, behavioral, and cognitive domains. In remote learners, there was a trend toward improvement in self-reported comfort across technical and cognitive domains in the telesimulation course. However, the only statistically significant improvement in postcourse surveys of telesimulation learners, compared with baseline, was in running codes. Regardless of the training modality, the students had a positive experience with the critical care simulation course, ranking it, on average, 9.6 out of 10 (9.9 in in-person simulation vs. 9.3 in telesimulation; P = 0.06). Conclusion We demonstrated that implementation of a telesimulation-based simulation course focusing on critical care cases is feasible and well received by trainees. Although a telesimulation-based simulation course may not be as effective for remote learners as active in-person participants, our study provided evidence that there was still a trend toward improving provider readiness across technical and cognitive domains when approaching critical care cases.

show abstract

Section: Discussionmentioning

confidence: 99%

Comparison of In-Person and Telesimulation for Critical Care Training during the COVID-19 Pandemic

2021

View full text Add to dashboard Cite

show abstract

“…Globally, 4-5% pregnant women are affected by PE, who face higher risks of seizures or falling into coma if the condition deteriorates into eclampsia, which threatens the life of both the mother and the baby ( 18 , 19 ). The past two decades have witnessed promising advances in terms of the accuracy and efficiency of PE diagnosis, in addition to improvements in the clinical management of this disease ( 20 , 21 ). However, the mechanism underlying the pathogenesis of PE remains to be fully elucidated ( 20 , 21 ).…”

Section: Discussionmentioning

confidence: 99%

“…The past two decades have witnessed promising advances in terms of the accuracy and efficiency of PE diagnosis, in addition to improvements in the clinical management of this disease ( 20 , 21 ). However, the mechanism underlying the pathogenesis of PE remains to be fully elucidated ( 20 , 21 ). Trophoblasts can differentiate into highly proliferative and invasive extravillous trophoblasts with physiology similar to that of cancer cells, which can invade the endometrium and anchor the placenta to the uterus ( 22 ).…”

Section: Discussionmentioning

confidence: 99%

Hes-related family BHLH transcription factor with YRPW motif 1-activated proteasome 26S subunit, non-ATPase 14 regulates trophoblast function and endometrial angiogenesis

Zhang

Zhang²,

Chen

2022

Exp Ther Med

View full text Add to dashboard Cite

Proteasome 26S subunit, non-ATPase 14 (PSMD14) expression has been previously reported to be reduced in patients with pre-eclampsia (PE). The present study investigated the interaction network associated with the role of PSMD14 in PE. Reverse transcription-quantitative PCR (RT-qPCR) and western blotting were performed to determine the transfection efficacy following plasmid-based gene transfer of PSMD14 into HTR-8/SVneo cells. Cell proliferation was measured using an MTT assay and 5-ethynyl-2'-deoxyuridine staining. The expression of proliferation-related proteins, including Ki67 and PCNA, was determined using western blotting. Wound healing and Transwell assays were performed to measure cell invasion and migration, whilst the expression of migration-related proteins, including MMP2 and MMP9, was measured using western blotting. The angiogenesis of HUVECs following treatment with the HTR-8/SVneo cell culture supernatant was examined using tube formation assay. Following overexpression of Hes-related family BHLH transcription factor with YRPW motif 1 (HEY1) by transfection of pcDNA3.1 expression vector containing full-length human HEY1 or knockdown by transfection of shRNA plasmids targeting HEY1, the expression of HEY1 and PSMD14 was detected using RT-qPCR and western blotting. The potential interaction between HEY1 and the PSMD14 promoter was examined using dual-luciferase reporter and chromatin immunoprecipitation assays. PSMD14 overexpression was found to promote the proliferation, invasion, migration of HTR-8/SVneo cells and the angiogenesis of HUVECs following treatment with the HTR-8/SVneo cell culture supernatant, accompanied by enhanced expression of proliferation and migration-related proteins. Furthermore, the transcription factor HEY1 activated the expression of PSMD14. Knocking down HEY1 expression partially reversed the promoting effects of PSMD14 overexpression on the proliferation, invasion, migration, angiogenesis, proliferation and migration-related protein expression in trophoblasts. In conclusion, HEY1-activated PSMD14 promoted trophoblast proliferation, invasion and angiogenesis. Therefore, HEY1 and PSMD14 can be potential targets for PE treatment.

show abstract

“…According to the national hospital discharge survey, the prevalence of hypertensive disorders in pregnancy (preeclampsia, eclampsia, gestational hypertension, and chronic hypertension) was estimated at 5.9% in the United States. The survey monitored about 39 million newborns over a 10-year period [ 15 , 16 ]. The study also showed that women with preeclampsia or eclampsia had a 3-25-fold increased risk of serious complications during their index pregnancies, including placental abruption, disseminated intravascular coagulation, pulmonary edema, and aspiration pneumonia [ 17 ].…”

Section: Discussionmentioning

confidence: 99%

Fetal Cerebral Hemodynamic Changes in Preeclampsia Patients by Ultrasonic Imaging under Intelligent Algorithm

Zhu

Ding

et al. 2022

Computational Intelligence and Neuroscience

View full text Add to dashboard Cite

This study was aimed at evaluating the adoption value of ultrasound imaging features on fetal cerebral hemodynamics in preeclampsia patients based on the partial difference algorithm and the hybrid segmentation network (HSegNet) algorithm. Forty pregnant women with preeclampsia diagnosed by ultrasound examination were selected as the research objects, and another forty normal pregnant women were selected as the control. Then, by using the partial differential algorithm, the imaging of fetal cerebral hemodynamics in preeclampsia patients was enhanced and optimized, and the general clinical data and experimental results were collected. The results showed that the automatic labeling of fetal cerebral artery in fetal middle cerebral artery (MCA) hemodynamic images was realized by HSegNet algorithm model, and the final accuracy was 97.3%, which had a good consistency with the manual annotation of doctors. Education level was a protective factor for preeclampsia (odds ratio (OR) = 0.535). Body mass index (BMI) and family history of hypertension during pregnancy were independent risk factors for preeclampsia (OR = 1.286, and 2.774, respectively). MCA end-diastolic volume (EDV) of preeclampsia fetuses was higher than that of normal fetuses. The MCA systolic-diastolic ratio (S/D), the pulsatility index (PI), and the resistive index (RI) in the preeclampsia group were significantly lower than those in the normal pregnancy group. The results showed that MCA PI, MCA RI, and MCA S/D had certain predictive values for the occurrence of adverse pregnancy outcomes ( P < 0.05 ). In summary, the intelligent algorithm-based fetal MCA hemodynamic ultrasound image in the study could effectively predict pregnancy outcomes of patients and provide certain theoretical support for the subsequent reduction of adverse pregnancy outcomes in patients with preeclampsia.

show abstract

Management of Pre-eclampsia and Eclampsia: A Simulation

Cited by 17 publications

References 8 publications

Comparison of In-Person and Telesimulation for Critical Care Training during the COVID-19 Pandemic

Comparison of In-Person and Telesimulation for Critical Care Training during the COVID-19 Pandemic

Hes-related family BHLH transcription factor with YRPW motif 1-activated proteasome 26S subunit, non-ATPase 14 regulates trophoblast function and endometrial angiogenesis

Fetal Cerebral Hemodynamic Changes in Preeclampsia Patients by Ultrasonic Imaging under Intelligent Algorithm

Contact Info

Product

Resources

About