Management of pregnancies complicated by anti-Fya alloimmunization

Hughes, Laura; Rossi, Karen; Krugh, Dave; O’Shaughnessy, R.

doi:10.1016/j.ajog.2004.10.480

Cited by 9 publications

(6 citation statements)

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“…Fy a ) have been reported to induce severe HDFN that requires intrauterine blood transfusion. This, however, rarely occurs . In our study, we observed no cases of severe HDFN in 42 antigen‐positive fetuses but phototherapy was needed in 14% of the cases, compared to 4% in controls (no antibodies present or antigen‐negative fetus) .…”

Section: Clinical Relevance Of Different Red Cell Alloantibody Specifcontrasting

confidence: 39%

Haemolytic disease of the fetus and newborn

et al. 2015

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Haemolytic Disease of the Fetus and Newborn (HDFN) is caused by maternal alloimmunization against red blood cell antigens. In severe cases, HDFN may lead to fetal anaemia with a risk for fetal death and to severe forms of neonatal hyperbilirubinaemia with a risk for kernicterus. Most severe cases are caused by anti-D, despite the introduction of antental and postnatal anti-D immunoglobulin prophylaxis. In general, red blood cell antibody screening programmes are aimed to detect maternal alloimmunization early in pregnancy to facilitate the identification of high-risk cases to timely start antenatal and postnatal treatment. In this review, an overview of the clinical relevance of red cell alloantibodies in relation to occurrence of HDFN and recent views on prevention, screening and treatment options of HDFN are provided.

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Section: Clinical Relevance Of Different Red Cell Alloantibody Specifcontrasting

confidence: 39%

Haemolytic disease of the fetus and newborn

et al. 2015

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“…Clinically, both antibodies against Fy a or Fy b may result in hemolytic disease of the newborn and hemolytic transfusion reactions . Moreover, several recent studies have shown that FY*A and FY*B polymorphism is associated with serum concentration of monocyte chemoattractant protein‐1 (MCP‐1) and affects susceptibility to Plasmodium vivax malaria .…”

Section: Introductionmentioning

confidence: 99%

A New Method for Analyzing the Duffy Blood Group Genotype by TaqMan Minor Groove Binding Probes

Zhou

Liu

An³

et al. 2014

Clinical Laboratory Analysis

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“…Anti‐Fy a immunization is frequent in multiply transfused patients and pregnant women. The prevalence of anti‐Fy a is nearly 10% after transfusion and ranges from 0.01% to 5.4% during pregnancy 3,9 . The risk of hemolytic disease of the fetus and newborn is usually moderate but severe fetal anemia can occur 10…”

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confidence: 99%