Management of primary hepatopancreatobiliary small cell carcinoma

Groeschl, Ryan T.; Christians, Kathleen K.; Turaga, Kiran K.; Gamblin, T. Clark

doi:10.1002/jso.23305

Cited by 15 publications

(12 citation statements)

References 17 publications

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“…[ 15 20 ] Primary small cell carcinoma, although rare, could be seen in the pancreas and should be included in the differential diagnosis metastatic small cell carcinoma. [ 15 33 34 ] Prior history of lung cancers including SCLC would be of great help for suggesting a metastasis. All of our patients with metastatic lung cancer had an either prior history or current biopsy to suggest a lung primary.…”

Section: Discussionmentioning

confidence: 99%

Endoscopic ultrasound-guided fine-needle aspiration diagnosis of secondary tumors involving the pancreas: An institution's experience

et al. 2016

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Background:Pancreatic masses may seldom represent a metastasis or secondary involvement by lymphoproliferative disorders. Recognition of this uncommon occurrence may help render an accurate diagnosis and avoid diagnostic pitfalls during endoscopic ultrasound-guided fine needle aspiration (EUS-FNA). In this study, we review our experience in diagnosing secondary tumors involving the pancreas.Materials and Methods:The electronic database of cytopathology archives was searched for cases of secondary tumors involving the pancreas at our institution and a total of 31 cases were identified. The corresponding clinical presentations, imaging study findings, cytological diagnoses, the results of ancillary studies, and surgical follow-up, if available, were reviewed.Results:Nineteen of the patients were male and 12 female, with a mean age of 66 years. Twenty-three patients (74%) had a prior history of malignancy, with the latency ranging from 6 months to 19 years. The secondary tumors involving the pancreas included metastatic carcinoma (24 cases), metastatic sarcoma (3 cases), diffuse large B-cell lymphoma (2 cases), and plasma cell neoplasm (2 cases). The most common metastatic tumors were renal cell carcinoma (8 cases) and lung carcinoma (7 cases). Correct diagnoses were rendered in 29 cases (94%). The remaining two cases were misclassified as primary pancreatic carcinoma. In both cases, the patients had no known history of malignancy, and no ancillary studies were performed.Conclusions:Secondary tumors involving the pancreas can be accurately diagnosed by EUS-FNA. Recognizing uncommon cytomorphologic features, knowing prior history of malignancy, and performing ancillary studies are the keys to improve diagnostic performance and avoid diagnostic pitfalls.

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Section: Discussionmentioning

confidence: 99%

Endoscopic ultrasound-guided fine-needle aspiration diagnosis of secondary tumors involving the pancreas: An institution's experience

et al. 2016

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“…Although surgical treatment of hgPNEC is controversial because most patients experience recurrent disease, reports discuss a beneficial effect of surgical treatment on survival. [10][11][12][13][14] These studies are either small case reports/series or larger series with lack of a well-defined comparative group.…”

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confidence: 99%

Surgical Treatment as a Principle for Patients with High-Grade Pancreatic Neuroendocrine Carcinoma: A Nordic Multicenter Comparative Study

et al. 2015

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“…Surgery is the mainstay of GB cancer treatment, but it is unclear whether radical operations produce better outcomes for advanced stages of SCC. Groeschl et al 3 analyzed the SEER (The Surveillance, Epidemiology, and End-Results) database between 1998 and 2008, in a study of hepatopancreatobiliary SCC, and concluded that surgical resection was associated with prolonged survival for patients with localized pancreatobiliary SCC. Of 32 patients with SCC of the GB, 24 (75%) received surgery.…”

Section: Discussionmentioning

confidence: 99%

“… 4 Although there is little experience with radiation for patients with SCC of the GB, it can be considered for use postoperatively, or to ameliorate symptoms, which are caused by an unresected tumor or metastasis. 3 …”

Section: Discussionmentioning

confidence: 99%

Small cell carcinoma of the gallbladder: a case report

Lee

Choi

Park

2017

Ann Hepatobiliary Pancreat Surg

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Small cell carcinoma (SCC) of the gallbladder is an extremely rare tumor. Despite aggressive and varied treatments, its prognosis is poor. A 70-year-old woman undergoing treatment for pneumonia was detected with a gallbladder mass. Radical cholecystectomy was performed and the pathology revealed small cell carcinoma. There were metastases in 2 lymph nodes, scoring T2N1M0, stage IIIB (AJCC 7th). The patient has survived thus far, with subsequent chemotherapy. SCC of the gallbladder has an extremely low incidence and poor prognosis. In some cases, radical surgery with chemotherapy or radiation therapy could increase survival rate of patients.

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Management of primary hepatopancreatobiliary small cell carcinoma

Cited by 15 publications

References 17 publications

Endoscopic ultrasound-guided fine-needle aspiration diagnosis of secondary tumors involving the pancreas: An institution's experience

Endoscopic ultrasound-guided fine-needle aspiration diagnosis of secondary tumors involving the pancreas: An institution's experience

Surgical Treatment as a Principle for Patients with High-Grade Pancreatic Neuroendocrine Carcinoma: A Nordic Multicenter Comparative Study

Small cell carcinoma of the gallbladder: a case report

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