Management of proctitis in ulcerative colitis and the place of biological therapies

De Deo, Diletta; Dal Buono, Arianna; Gabbiadini, Roberto; Spaggiari, Paola; Busacca, Anita; Masoni, Benedetta; Ferretti, Silvia; Bezzio, Cristina; Armuzzi, Alessandro

doi:10.1080/14712598.2024.2369189

Expert Opinion on Biological Therapy

2024

DOI: 10.1080/14712598.2024.2369189

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Management of proctitis in ulcerative colitis and the place of biological therapies

Diletta De Deo,

Arianna Dal Buono,

Roberto Gabbiadini

et al.

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2024

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Cited by 2 publications

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Letter: Ulcerative proctitis—A step towards addressing the knowledge gap, and a call for greater detail, in trial data—Authors' reply

Ferreiro‐Iglesias,

Barreiro‐de Acosta

2024

Aliment Pharmacol Ther

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Letter: Ulcerative proctitis—A step towards addressing the knowledge gap, and a call for greater detail, in trial data—Authors' reply

Ferreiro‐Iglesias,

Barreiro‐de Acosta

2024

Aliment Pharmacol Ther

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Inhibition of the Wnt/β‑catenin signaling pathway and SOX9 by XAV939 did not alleviate inflammation in a dextran sulfate sodium‑induced ulcerative colitis model

Liang,

Wang,

Mao

et al. 2024

Exp Ther Med

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The Wnt/β-catenin signaling pathway has been reported to be hyperactivated during the pathogenesis of ulcerative colitis (UC). The present study aimed to explore the therapeutic efficacy of the Wnt/β-catenin signaling inhibitor XAV939 in mitigating UC symptoms. Utilizing a dextran sulfate sodium (DSS)-induced UC mouse model, the present study aimed to evaluate the impact of XAV939 on intestinal morphology through hematoxylin and eosin staining and to measure the expression levels of critical proteins in the Wnt/β-catenin signaling cascade. XAV939 did not exert a significant influence on the morphological features and inflammatory status of the intestinal epithelium. However, XAV939 was found to effectively suppress the Wnt/β-catenin signaling pathway and its downstream target SOX9. This suppression implied a reduction in the differentiation of intestinal stem cells into secretory cell progenitor cells. Additionally, XAV939 was ineffective at reversing the DSS-induced decrease in expression levels of Villin and peroxisome proliferator-activated receptor γ, which suggested that it did not facilitate the differentiation of intestinal absorptive cells. The present findings indicated that the Wnt/β-catenin signaling pathway may not be the predominant mechanism in the pathogenesis of DSS-induced UC.

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Management of proctitis in ulcerative colitis and the place of biological therapies

Cited by 2 publications

References 93 publications

Letter: Ulcerative proctitis—A step towards addressing the knowledge gap, and a call for greater detail, in trial data—Authors' reply

Letter: Ulcerative proctitis—A step towards addressing the knowledge gap, and a call for greater detail, in trial data—Authors' reply

Inhibition of the Wnt/β‑catenin signaling pathway and SOX9 by XAV939 did not alleviate inflammation in a dextran sulfate sodium‑induced ulcerative colitis model

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