Management of Radiation-Induced Early Nasal Adhesion after Radiotherapy for Nasopharyngeal Carcinoma

Xiang, Liangzhong; Liang, Fa; Han, Ping; Zhang, Hua; Chen, Qiujian; Jiang, Xiaoyu; Li, Rui-chen; Huang, Xiaoming

doi:10.2500/ajra.2013.27.3915

Cited by 8 publications

(9 citation statements)

References 15 publications

(23 reference statements)

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“…Nasal irrigation can reduce the nasal swelling, dryness, nasal obstruction, and other adverse reactions of NPC patients after radiotherapy. It can also promote normal mucosal repair and reduce the incidence of complications [ 22 ]. After the patient is discharged, it is necessary to improve the compliances using nasal lavage.…”

Section: Discussionmentioning

confidence: 99%

Use of a Smartphone Medical App Improves Complications and Quality of Life in Patients with Nasopharyngeal Carcinoma Who Underwent Radiotherapy and Chemotherapy

2018

Med Sci Monit

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BackgroundWe explored the intervention effect of a smartphone medical app on complications and quality of life of patients with nasopharyngeal carcinoma who underwent radiotherapy and chemotherapy.Material/MethodsWe divided 132 patients with nasopharyngeal carcinoma who received radiotherapy and chemotherapy for the first time, in accordance with the random number table method, into a control group (67 patients) and an intervention group (65 patients). Patients in control group were discharged with standard care and patients in the intervention group used a smartphone medical app after discharge. Data on adverse effects of radiotherapy and chemotherapy, complications, and quality of life were collected and analyzed.ResultsThere was no difference between the complications of radiotherapy and chemotherapy and quality of life between the 2 groups at discharge (P>0.05). The incidence of oral mucositis, xerostomia, mouth-opening difficulties, and nasal congestion in the intervention group was significantly lower than in the control group at 6 months after discharge and quality of life was significantly higher than in the control group (P<0.05).ConclusionsReasonable use of this smartphone app can improve the exercise compliance of discharged patients with nasopharyngeal carcinoma who underwent radiotherapy and chemotherapy, reduce the adverse reactions and complications of radiotherapy and chemotherapy, and improve quality of life and satisfaction of patients after discharge.

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Section: Discussionmentioning

confidence: 99%

Use of a Smartphone Medical App Improves Complications and Quality of Life in Patients with Nasopharyngeal Carcinoma Who Underwent Radiotherapy and Chemotherapy

2018

Med Sci Monit

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“…Acquired nasal cavity stenosis is diagnosed using TNE when nasal obstruction, adhesion, or changes in mucosal morphology that cannot be restored using a vasoconstrictor occur. Furthermore, acquired nasal cavity atresia is diagnosed if a blind end is detected using endoscopy [8].…”

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confidence: 99%

“…The prevalence of ANCSA ranges from 10.7% to 43.5% in patients with NPC, and it has only been investigated in a few studies involving small sample sizes [9,10]. ANCSA can lead to various symptoms, including hypoxemia, headache, anosmia, sinusitis, aggravation of xerostomia, and increased difficulty of early detection of recurrence or nasopharyngeal necrosis [8,11,12]. Development of early-stage nasal cavity adhesion can be prevented using a simple TNE examination, which indicates that early detection is essential for preventing aggravation of such complications.…”

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confidence: 99%

“…Development of early-stage nasal cavity adhesion can be prevented using a simple TNE examination, which indicates that early detection is essential for preventing aggravation of such complications. Liu et al [8] reported that the management of early-stage ANCSA using TNE substantially reduced symptoms of xerostomia, obstruction, and anosmia. Compared to surgery for severe nasal cavity stenosis and atresia, disease management using TNE at an early stage was shown to be easier, safer, and more efficient [16].…”

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confidence: 99%

“…Compared to surgery for severe nasal cavity stenosis and atresia, disease management using TNE at an early stage was shown to be easier, safer, and more efficient [16]. However, most studies have focused on various management strategies for advanced stages of ANCSA, including transnasal endoscopic resection, temperaturecontrolled radio frequency repair, and the application of septonasal bidirectional mucoperiosteal flap [8][9][10][11][13][14][15][16]. Risk factors associated with ANCSA after radical radiotherapy for NPC must be urgently identified to distinguish patients at high risk, thus enabling early detection and management.…”

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Development and validation of a normal tissue complication probability model for acquired nasal cavity stenosis and atresia after radical radiotherapy for nasopharyngeal carcinoma

Yan

Guo

Lin

et al. 2021

Radiotherapy and Oncology

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Purpose: Curative radiotherapy for nasopharyngeal carcinoma (NPC) can lead to acquired nasal cavity stenosis and atresia (ANCSA). As the first study to investigate risk factors of ANCSA in a large cohort of NPC patients, this article aims to develop and validate a multivariate normal tissue complication probability (NTCP) model to predict the development of ANCSA and to establish a nomogram for clinical use. Methods and materials: The retrospective cohort was comprised of 548 NPC patients treated with radical radiotherapy. The cohort was randomly divided into training and validation groups. Least absolute shrinkage and selection operator regression was performed for variable selection from the clinical and dosimetric characteristics in the training group. A multivariate NTCP model and a nomogram were established for the prediction of ANCSA development. Discrimination and calibration were tested using receiver operating characteristic (ROC) curves and calibration tests, respectively, for both groups. Results: ANCSA was observed in 132 (24.1%) of 548 patients with NPC who underwent radical radiotherapy. The median time to ANCSA detection after treatment was 2.8 months (range, 0.0-57.7 months). Five potential predictors, including choanal invasion, low white blood cell count, high C-reactive protein level, high serum amyloid A level, and high V70Gy of the nasal cavity, were selected to develop the NTCP model based on 365 patients in the training group. The model had a fairly good discriminative power according to the ROC analysis in both the training (area under ROC curve = 0.79, 95%CI: 0.73-0.84) and validation (0.73, 0.64-0.82) groups. The calibration power was tested using the calibration test in the training (Emax = 0.069, E-avg = 0.015, p = 0.977) and validation (E-max = 0.057, E-avg = 0.032, p = 0.747) groups. Conclusions: We developed and successfully validated an NTCP model for early prediction of ANCSA in patients with NPC after radical radiotherapy. This could help clinicians assess the risk of ANCSA before the initiation of follow-ups and ensure appropriate and timely management of this complication.

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Clinical and dosimetric predictors of radiation-induced rhinosinusitis following VMAT for nasopharyngeal carcinoma: A retrospective study

Bao,

Wang,

et al. 2024

Heliyon

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Management of Radiation-Induced Early Nasal Adhesion after Radiotherapy for Nasopharyngeal Carcinoma

Abstract: Therapeutic endoscopy in combination with nasal steroid sprays and nasal irrigation provides a convenient, simple, effective, and minimally invasive therapy to treat early radiation-induced nasal adhesion patients.

Cited by 8 publications

References 15 publications

Use of a Smartphone Medical App Improves Complications and Quality of Life in Patients with Nasopharyngeal Carcinoma Who Underwent Radiotherapy and Chemotherapy

Use of a Smartphone Medical App Improves Complications and Quality of Life in Patients with Nasopharyngeal Carcinoma Who Underwent Radiotherapy and Chemotherapy

Development and validation of a normal tissue complication probability model for acquired nasal cavity stenosis and atresia after radical radiotherapy for nasopharyngeal carcinoma

Clinical and dosimetric predictors of radiation-induced rhinosinusitis following VMAT for nasopharyngeal carcinoma: A retrospective study

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