Management of recurrent acute otitis media in children: systematic review of the effect of different interventions on otitis media recurrence, recurrence frequency and total recurrence time

Cheong, Kai-Ning; Hussain, S. S. M.

doi:10.1017/s0022215112001338

Cited by 25 publications

(23 citation statements)

References 26 publications

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“…[20] However, this study did not provide a definition of recurrent URIs, recurrent otitis, or recurrent pneumonia, making it difficult to compare the reported prevalence with the population-level prevalence, particularly when as many as 46% of children in the general population have three or more episodes of otitis media by three years of age. [21] In another study, the prevalence of recurrent URI (defined as 3 episodes per year for 3 successive years) and recurrent UTI (defined as 3 episodes over a 2 year period) was 42% and 9%, respectively, [14] One study of SIgAD patients found that 57.84% had atopic dermatitis, although only 10.17% of those had elevated IgE. [28] These studies are generally small, yielding significant variability between resulting prevalence estimates.…”

Section: Complicationsmentioning

confidence: 99%

The Epidemiology and Clinical Manifestations of Autoimmunity in Selective IgA Deficiency

Odineal

Gershwin

2019

Clinic Rev Allerg Immunol

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Selective Immunoglobulin A Deficiency (SIgAD) is the most common primary immunodeficiency, defined as an isolated deficiency of IgA (less than 0.07 g/L). Although the majority of people born with IgA deficiency lead normal lives without significant pathology, there is nonetheless a significant association of IgA deficiency with mucosal infection, increased risks of atopic disease, and a higher prevalence of autoimmune disease. To explain these phenomena, we have performed an extensive literature review to define the geoepidemiology of IgA deficiency and particularly the relative risks for developing Systemic Lupus Erythematosus, hyperthyroidism, hypothyroidism, type 1 diabetes mellitus, Crohn's Disease, ulcerative colitis, rheumatoid arthritis, juvenile idiopathic arthritis, ankylosing spondylitis, and vitiligo; these diseases have strong data to support an association. We also note weaker associations with scleroderma, celiac disease, autoimmune hepatitis, immune thrombocytopenic purpura, and autoimmune hemolytic anemia. Minimal if any associations are noted with myasthenia gravis, lichen planus, and multiple sclerosis. Finally, more recent data provide clues on the possible immunologic mechanisms that lead to the association of IgA deficiency and autoimmunity; these lessons are important for understanding the etiology of autoimmune disease. 2 3 Introduction:

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Section: Complicationsmentioning

confidence: 99%

The Epidemiology and Clinical Manifestations of Autoimmunity in Selective IgA Deficiency

Odineal

Gershwin

2019

Clinic Rev Allerg Immunol

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“…Children aged less than six months are considered high risk because recurring bouts of otitis media may predispose them to complications that include speech difficulties and hearing loss. 1,2 In our study, we reported the highest incidences of non-resolving acute otitis media following initial paracetamol usage in children aged 7-12 months (43.5 per cent) and 2-5 years (42.1 per cent). 3 In chronic suppurative otitis media (CSOM) where microbial aetiology is implicated, it is important that antibiotics be given.…”

Section: Authors' Replymentioning

confidence: 54%

Occurrence of otitis media in children and assessment of treatment options

Bakshi

2015

J. Laryngol. Otol.

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“…10,11 Review study by Cheong et al which compares the effects of interventions by prophylactic antibiotics, tympanostomy tube insertion and adenoidectomy concluded that prophylactic antibiotics are effective in reducing otitis media recurrence, recurrence frequency and total recurrence time. 12 There are several studies where a single antibiotic versus placebo control or comparison between antibiotics like amoxicillin, septran, macrolides etc. have been made with a result that prophylactic antibiotics are effective in the management of recurrent AOM.…”

Section: Discussionmentioning

confidence: 99%

A study on the efficacy of prophylactic antibiotics in recurrent acute otitis media

Vijayakumar

Santhi

2019

Int J Otorhinolaryngol Head Neck Surg

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Background: To study the efficacy of broad spectrum antibiotics in the prophylaxis of recurrent acute otitis media.Methods: 86 patients of age group between 2 and 15 years with history of recurrent otitis media were enrolled to study the efficacy of the prophylactic antibiotics used in this condition. The children were treated with amoxicillin or azithromycin during the acute episode. Then they were divided equally into two groups and assigned to receive amoxicillin in one group and azithromycin in the other group at one third the therapeutic dose as prophylaxis for 6 months. The children were evaluated at the end of every month and recurrent episodes if any, was documented. Results: At the end of 6 months it was observed that prophylactic antibiotics were more effective in the younger age group of 2-7 years. Efficacy rates of 87.5% with azithromycin and 77.4% with amoxicillin were noted.Conclusions: As azithromycin is given once a week compared to amoxicillin which is given daily and was found to be equally effective as a prophylactic drug in recurrent acute otitis media with a better compliance, it is a good alternative to amoxicillin as a prophylactic antibiotic. Proper dosage goes a long way in bringing down resistance to the therapeutic agents.

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Management of recurrent acute otitis media in children: systematic review of the effect of different interventions on otitis media recurrence, recurrence frequency and total recurrence time

Cited by 25 publications

References 26 publications

The Epidemiology and Clinical Manifestations of Autoimmunity in Selective IgA Deficiency

The Epidemiology and Clinical Manifestations of Autoimmunity in Selective IgA Deficiency

Occurrence of otitis media in children and assessment of treatment options

A study on the efficacy of prophylactic antibiotics in recurrent acute otitis media

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