Management of recurrent bilateral multifocal pseudoangiomatous stromal hyperplasia (PASH)

Xu, Xiaoting; Persing, Sarah; Allam, Omar; Park, Kitae E; Mozaffari, Mohammad Ali; Lannin, Donald R.; Bossuyt, Veerle; Alperovich, Michael

doi:10.1111/tbj.13950

Cited by 5 publications

(4 citation statements)

References 17 publications

(29 reference statements)

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“…In some cases, total mastectomy is performed [ 6 ]. Moreover, some patients who underwent breast reduction did not develop complications [ 7 ], while others required total mastectomy because a recurrence occurred after reduction [ 8 ]. It is difficult to reach an accurate consensus on the recurrence rate and prognosis according to treatment methods.…”

Section: Discussionmentioning

confidence: 99%

Pseudoangiomatous Stromal Hyperplasia of the Breast in a Female Adolescent Presenting as Bilateral Gigantomastia

et al. 2023

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Pseudoangiomatous stromal hyperplasia (PASH) is a rare idiopathic proliferative mesenchymal breast disease related to hormonal imbalance, and thus extremely rare in children and adolescents. In addition, PASH manifests as a bilateral gigantomastia in some cases with no established cause or treatment. Here, we report a case of a rapidly developed PASH presenting with bilateral gigantomastia in a 14-year-old premenarchial female patient. Considering the patient’s age and emotions and the need for nipple-areolar complex repositioning, we performed reduction mammoplasty rather than total mastectomy despite the possibility of recurrence. Although some masses could not be completely removed, no complications, such as infection, wound dehiscence, or hematoma occurred postoperatively. The patient was stable during the 18-month follow-up period, although an evidence of recurrent and residual disease was noted upon ultrasonography.

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Section: Discussionmentioning

confidence: 99%

Pseudoangiomatous Stromal Hyperplasia of the Breast in a Female Adolescent Presenting as Bilateral Gigantomastia

et al. 2023

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“…Sometimes, for an accurate diagnosis, an IHC examination is also needed. The mesenchymal cells of PASH express vimentin, CD34 (an endothelial cell marker), actin, desmin, calponin, and progesterone receptor, but not CD31 (vascular marker) or factor VIII (endothelial cell marker) [ 5 , 12 , 19 ]. In this case, the patient had an enlargement of the collagen fibers in the breasts, in which many fissures were formed and coincided with each other.…”

Section: Discussionmentioning

confidence: 99%

“…Hence, the final diagnosis of PASH relies on histopathology and immunohistochemistry (IHC) [ 4 ]. Local mass removal is a common surgical procedure but recurrence can occur, especially in patients with multifocal PASH [ 5 ]. The clinical manifestations of PASH include a tumor-forming lesion (tumorous PASH) or gigantomastia (diffuse PASH).…”

Section: Introductionmentioning

confidence: 99%

“…The clinical manifestations of PASH include a tumor-forming lesion (tumorous PASH) or gigantomastia (diffuse PASH). Most of the cases addressed in the past were unilateral tumour PASH, and very few cases of bilateral PASH have been recorded [ 5 , 6 ]. In this article, we describe a rare case of bilateral multicenter tumorous PASH in a patient that underwent total mastectomy and one-stage implant-based breast reconstruction.…”

Section: Introductionmentioning

confidence: 99%

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