Management of recurrent implantation failure: British Fertility Society policy and practice guideline

Mascarenhas, Mariano; Jeve, Yadava; Polański, Łukasz; Sharpe, Abigail; Yasmin, Ephia; Bhandari, Harish M

doi:10.1080/14647273.2021.1905886

Cited by 27 publications

(21 citation statements)

References 183 publications

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“…Several management protocols have been proposed so far, including endometrial scratching, adjuvant glucocorticoid administration, intravenous immunoglobulin (IVIg) administration, and intralipid therapy. However, none of the aforementioned management protocols have been proven conclusively efficient to the extent of leading to a consensus [16,140,141]. In contrast, clinicians should be aware that the liberal use of these immunoregulatory treatments could not only be inadequate, but in certain circumstances, could even be rendered harmful.…”

Section: Discussionmentioning

confidence: 99%

“…The controversial criteria, indicating its highly variable nature, include the number of failed IVF cycles, the number of embryos transferred as well as maternal age [10,13]. Despite the fact that several definitions have been proposed, the most widely accepted is the one described by the failure to achieve a positive pregnancy test following three or more consecutive transfers of good quality embryos [10,11,[13][14][15][16]. The discrepancies regarding RIF definition have led to a lack of a standardized, efficient, and universally accepted protocol for RIF management, making RIF one of the most challenging conditions reproductive scientists should deal with in daily clinical practice [16].…”

Section: Introductionmentioning

confidence: 99%

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The Role of Interleukins in Recurrent Implantation Failure: A Comprehensive Review of the Literature

Pantos¹,

Grigoriadis

Maziotis

et al. 2022

IJMS

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Recurrent implantation failure (RIF) is a multifactorial condition affecting 10–15% of in vitro fertilization (IVF) couples. Data suggest that functional dysregulation of the endometrial immune system constitutes one of the main pathophysiological mechanisms leading to RIF. The aim of this article is to provide a thorough presentation and evaluation of the role of interleukins (ILs) in the pathogenesis of RIF. A comprehensive literature screening was performed summarizing current evidence. During implantation, several classes of ILs are secreted by epithelial and stromal endometrial cells, including IL-6, IL-10, IL-12, IL-15, IL-18, and the leukemia inhibitory factor. These ILs create a perplexing network that orchestrates both proliferation and maturation of uterine natural killer cells, controls the function of regulatory T and B cells inhibiting the secretion of antifetal antibodies, and supports trophoblast invasion and decidua formation. The existing data indicate associations between ILs and RIF. The extensive analysis performed herein concludes that the dysregulation of the ILs network indeed jeopardizes implantation leading to RIF. This review further proposes a mapping of future research on how to move forward from mere associations to robust molecular data that will allow an accurate profiling of ILs in turn enabling evidence-based consultancy and decision making when addressing RIF patients.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The Role of Interleukins in Recurrent Implantation Failure: A Comprehensive Review of the Literature

Pantos¹,

Grigoriadis

Maziotis

et al. 2022

IJMS

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“…A similar issue continues to afflict trials of interventions for recurrent miscarriage [13]. Unless we change the way in which see RIF and recognize that effective treatment requires a diagnosis of its cause in an individual patient, it will be difficult to progress beyond the present clinical impasse in which we have landed in which are seeking to treat a condition we have been unable to define with interventions that don't appear to work [14][15][16]. The studies…”

Section: Discussionmentioning

confidence: 99%

The true incidence of recurrent implantation failure

Macklon

2022

Current Opinion in Obstetrics &Amp; Gynecology

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Purpose of reviewTo review the merits and limitations of current definitions of recurrent implantation failure (RIF), how they translate into estimates of incidence and to summarize how emerging concepts of individualizing the recognition of this condition can assist in changing the way RIF is identified, studied and managed.Recent findingsThe notion of a one size fits all definition of RIF is seen to be of limited clinical value, as the individual risk of repeated IVF failure has many determinants and causes. Novel approaches provide a means of identifying ‘actionable’ RIF in individual patients.SummaryUncertainties as to what constitutes, causes and defines RIF have served to limit progress in its management. A new approach promises to permit progress from the current impasse.

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“…Although reported success rates in assisted reproduction approach or even surpass natural conceptions, 1-2 % of couples will experience recurrent implantation failure, defined as the absence of a positive pregnancy test after three transfers of high-quality embryos (Mascarenhas et al, 2021). dynamics vary greatly between humans and mice (Teilmann et al, 2006) and decidualisation in mouse is dependent on an embryonic stimulus (Lopes et al, 2004) rather than a spontaneous cyclic process.…”

Section: Introductionmentioning

confidence: 99%

“…Although reported success rates in assisted reproduction approach or even surpass natural conceptions, 1–2% of couples will experience recurrent implantation failure, defined as the absence of a positive pregnancy test after three transfers of high-quality embryos ( Mascarenhas et al 2021 ). Some will never achieve a successful pregnancy even in the absence of a confirmed dysfunction.…”

Section: Introductionmentioning

confidence: 99%

Organoids to model the endometrium: implantation and beyond

Rawlings

Makwana

Tryfonos

et al. 2021

Reproduction and Fertility

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Despite advances in assisted reproductive techniques in the four decades since the first human birth after in vitro fertilisation, 1-2 % of couples experience recurrent implantation failure, and some will never achieve a successful pregnancy even in the absence of a confirmed dysfunction. Furthermore, 1-2 % of couples who do conceive, either naturally or with assistance, will experience recurrent early loss of karyotypically normal pregnancies. In both cases, embryo-endometrial interaction is a clear candidate for exploration. The impossibility of studying implantation processes within the human body has necessitated the use of animal models and cell culture approaches. Recent advances in 3-dimensional modelling techniques, namely the advent of organoids, present an exciting opportunity to elucidate the unanswerable within human reproduction. In this review, we will explore the ontogeny of implantation modelling and propose a roadmap to application and discovery.

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Management of recurrent implantation failure: British Fertility Society policy and practice guideline

Cited by 27 publications

References 183 publications

The Role of Interleukins in Recurrent Implantation Failure: A Comprehensive Review of the Literature

The Role of Interleukins in Recurrent Implantation Failure: A Comprehensive Review of the Literature

The true incidence of recurrent implantation failure

Organoids to model the endometrium: implantation and beyond

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