Management of Refractory Mandibular Kaposiform Hemangioendothelioma with Sirolimus: A Case Report and Review of the Literature

Aggressive vascular tumor mimicking posttraumatic hematoma: A case report of kaposiform hemangioendothelioma on the nose

“… 5 Yet, several reports suggest a link between local trauma, biopsy, or infection. 6 , 7 , 8 Others report a link between trauma or vaccination and the development of KMP in patients with KHE. 9 , 10 These findings raise the suggestion that trauma and inflammation contribute to the aggravation of KHE.…”

Digital subtraction angiography and trans arterial embolization in preventing massive hemorrhage of Kaposiform hemangioendothelioma: A case report

“…Side effects of steroid treatment are hypertension, obesity, acne, growth and developmental disorders, Cushingoid appearance, and higher risk of opportunistic infection caused by its anti-proliferative and anti-angiogenic effects. Steroids cannot be given to children under one year of age due to the increased risk of spastic diplegia [12] .…”

“…There is a rather high risk of surgical mortality in neonate and pediatric patients. Embolization also carries a risk of causing cerebral infarcts and loss of function of both extremities [12] . Chemotherapy with vincristine, vinca alkaloids is not only given in KHE, but also in other lymphoproliferative disorders.…”

“…In younger patients, the agent can be administered orally. Sirolimus also causes fewer side effects compared to vincristine, without recurrence in the first year [12] .…”