Management of Restless Legs Syndrome With Gabapentin (Neurontin®)

Cloning and Deletion Mutagenesis of the α2δ Calcium Channel Subunit from Porcine Cerebral Cortex

“…Recent research suggests that gabapentin may also have clinical utility for anxiety (10,11), pain (11-15), restless leg syndrome (16), and hemifacial spasms (17). Although designed as a lipophilic GABA-mimetic, gabapentin does not have a high affinity for either GABA A or GABA B receptors (18), GABA uptake sites, or the GABAdegrading enzyme GABA-transaminase (EC 2.6.1.19) (19,20).…”

Unmet Needs in the Treatment of Allergic Asthma: Potential Role of Novel Biologic Therapies

“…One concern when developing such categorizations is that there is no singular consensus about a standardized classification scheme. 48 Indeed, while clinicians will no doubt disagree about clinical significance, there is also a lack of uniformity about potential severity of DDIs across commonly used reference materials, 49 making classifications of such interactions even more difficult. In any case, our data suggest that there may be differences in the clinical relevance of automated alerts and that varying levels of manual input are needed to ferret out the true positive from the false positive warnings.…”

Restless legs syndrome: an unusual cause for a perplexing syndrome

“…3,7,9,19 However, the side-e ects of L-dopa include augmentation or rebound; 20 Benzodiazepines, 9 narcotics and more recently gabapentin. 3,21 Other useful agents mentioned are beta-blockers, serotonin precursors, tricyclic antidepressants, acetaminophen and red wine. 2,22 When RLS is associated with an underlying medical disorder or de®ciency state, treatment of the underlying condition may alleviate the symptoms.…”