Purpose To evaluate the efficacy and safety of Artisan-Verysise intraocular lens (IOL) secondarily implanted for aphakic correction in post-traumatic vitrectomized eyes. Methods Postoperative outcomes of secondary implantation of an iris-supported Artisan IOL in 17 unilateral aphakic patients with previous pars plana vitrectomy secondary to posterior segment trauma were evaluated prospectively. Eyes had vitrectomized in previous 6-60 months. After complete ophthalmologic examination, IOL implantation was performed through a scleral tunnel incision. Patients were followed for visual outcome, endothelial cell density (ECD) and occurrence of complications. Uncorrected visual acuity (UCVA), best-corrected visual acuity (BCVA), spherical equivalents (SE), and ECD were compared before and after IOL insertion. Conclusion Secondary Artisan IOL implantation is an effective and safe procedure to correct aphakia in vitrectomized eyes without capsular support after trauma. Considering good visual rehabilitation and low rate of complications, this procedure is recommended in vitrectomized eyes.