Management of Schizophrenia with Medical Disorders: Cardiovascular, Pulmonary, and Gastrointestinal

Short, Delmar; Hawley, Joanne M.; McCarthy, Maureen Fay

doi:10.1016/j.psc.2009.09.005

Cited by 7 publications

(7 citation statements)

References 33 publications

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“…These overlapping effects are mostly characterized by increased fetal expression of inflammatory factors, such as proinflammatory cytokines and chemokines (5). It is believed that abnormal expression of inflammatory factors in the fetal brain contribute to, or even mediate, abnormal brain and behavioral development following prenatal exposure to infection (79,136). Indeed, as reviewed extensively elsewhere (95,102), acute inflammation during early fetal brain development may negatively affect ongoing neurodevelopmental processes, such as neuronal/glial cell differentiation, proliferation, migration, and survival, and, thus, predispose the developing offspring to long-term brain and behavioral dysfunctions.…”

Section: Peripheral (And Central) Inflammationmentioning

confidence: 99%

“…Indeed, in addition to the pathological symptoms traditionally attributed to CNS dysfunctions, neurodevelopmental psychiatric illnesses, such as autism and schizophrenia, are also associated with a number of GI dysfunctions. Such abnormalities include chronic intestinal low-grade inflammation, increased intestinal permeability ("leaky gut"), allergic reactions to dietary proteins, diarrhea, gastric dysmobility, and alterations in gut microbiota (16,26,133,136). By further undermining general physical health and daily life quality, GI distress induces an additional clinical burden to patients suffering from psychiatric disorders (9,53).…”

Section: Gastrointestinal Abnormalities and Dysbiosismentioning

confidence: 99%

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Long-term pathological consequences of prenatal infection: beyond brain disorders

Labouesse

Langhans

Meyer

2015

American Journal of Physiology-Regulatory, Integrative and Comp

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Section: Peripheral (And Central) Inflammationmentioning

confidence: 99%

Section: Gastrointestinal Abnormalities and Dysbiosismentioning

confidence: 99%

Long-term pathological consequences of prenatal infection: beyond brain disorders

Labouesse

Langhans

Meyer

2015

American Journal of Physiology-Regulatory, Integrative and Comp

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“…According to the description of the 43 adverse drug interactions, 41 were related to increased risk of cardiotoxicity and arrhythmias, which indicated that the coadministration of SCZ drugs might increase the risk of heart disease, especially for prolonging QT intervals [26]. …”

Section: Resultsmentioning

confidence: 99%

Characterization of Schizophrenia Adverse Drug Interactions through a Network Approach and Drug Classification

Sun

Zhao

Fanous

et al. 2013

BioMed Research International

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Antipsychotic drugs are medications commonly for schizophrenia (SCZ) treatment, which include two groups: typical and atypical. SCZ patients have multiple comorbidities, and the coadministration of drugs is quite common. This may result in adverse drug-drug interactions, which are events that occur when the effect of a drug is altered by the coadministration of another drug. Therefore, it is important to provide a comprehensive view of these interactions for further coadministration improvement. Here, we extracted SCZ drugs and their adverse drug interactions from the DrugBank and compiled a SCZ-specific adverse drug interaction network. This network included 28 SCZ drugs, 241 non-SCZs, and 991 interactions. By integrating the Anatomical Therapeutic Chemical (ATC) classification with the network analysis, we characterized those interactions. Our results indicated that SCZ drugs tended to have more adverse drug interactions than other drugs. Furthermore, SCZ typical drugs had significant interactions with drugs of the “alimentary tract and metabolism” category while SCZ atypical drugs had significant interactions with drugs of the categories “nervous system” and “antiinfectives for systemic uses.” This study is the first to characterize the adverse drug interactions in the course of SCZ treatment and might provide useful information for the future SCZ treatment.

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“…The primary causes of reduction in consumers’ lifespans are premature coronary heart and cerebrovascular diseases (Short et al . 2009), with up to 60% of this excess mortality being attributable to common preventable and treatable medical conditions (Tse et al . 2011).…”

Section: Introductionmentioning

confidence: 99%

Mental health consumers' with medical co‐morbidity experience of the transition through tertiary medical services to primary care

Cranwell

Polacsek

McCann

2016

Int J Mental Health Nurs

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Medical comorbidity in people with long‐term mental illness is common and often undetected; however, these consumers frequently experience problems accessing and receiving appropriate treatment in public health‐care services. The aim of the present study was to understand the lived experience of mental health consumers with medical comorbidity and their carers transitioning through tertiary medical to primary care services. An interpretative, phenomenological analysis approach was used, and semistructured, video‐recorded, qualitative interviews were used with 12 consumers and four primary caregivers. Four main themes and related subthemes were abstracted from the data, highlighting consumer's and carers’ experience of transition through tertiary medical to primary care services: (i) accessing tertiary services is difficult and time consuming; (ii) contrasting experiences of clinician engagement and support; (iii) lack of continuity between tertiary medical and primary care services; and (iv) Mental Health Hospital Admission Reduction Programme (MH HARP) clinicians facilitating transition. Our findings have implications for organisational change, expanding the role of MH HARP clinicians (whose primary role is to provide consumers with intensive support and care coordination to prevent avoidable tertiary medical hospital use), and the employment of consumer and carer consultants in tertiary medical settings, especially emergency departments.

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Management of Schizophrenia with Medical Disorders: Cardiovascular, Pulmonary, and Gastrointestinal

Cited by 7 publications

References 33 publications

Long-term pathological consequences of prenatal infection: beyond brain disorders

Long-term pathological consequences of prenatal infection: beyond brain disorders

Characterization of Schizophrenia Adverse Drug Interactions through a Network Approach and Drug Classification

Mental health consumers' with medical co‐morbidity experience of the transition through tertiary medical services to primary care

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