Management of Seasonal Anestrus: Hormone Therapy

McCue, Patrick M.

doi:10.1002/9781118904398.ch46

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“…The exact mechanism of action of catecholamines, DA in particular, on follicular dynamics is not known, but is believed to involve the regulation of prolactin as its pituitary production, which primarily is regulated through inhibition by the neurotransmitter DA. The DA antagonist increases the circulating prolactin and estradiol concentrations after the first week of treatment, indicating a follicular development as a result of inhibition of DA and increased stimulation of gonadotrophin receptors on the ovary [ 36 ]. However, the DA antagonists allow follicular development only in the presence of FSH secretion and the ability of the ovary to respond to them in the mare.…”

Section: Discussionmentioning

confidence: 99%

Intrafollicular and Systemic Dopamine, Noradrenaline and Adrenaline Concentrations in Cycling Mares

Satué

Fazio

Rubio

et al. 2020

Animals

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In some species, catecholamines in follicular fluid (FF) are related to local physiological events responsible for the regulation of ovarian functions and oocyte maturation. The aim of the present study was to determine and compare intrafollicular and systemic concentrations of dopamine (DA), noradrenaline (NA) and adrenaline (AD) in cycling mares. Sixty ovaries were collected during breeding season from 30 mares raised for slaughterhouse meat production, with clinically normal reproductive tracts, were evaluated. Blood samples were collected prior to slaughter. Follicles were classified into three categories in relation to size: small (20–30 mm; n = 20), medium (≥31–40 mm; n = 20) and large (≥41 mm; n = 20). Follicular fluid (FF) samples were extracted from each follicle. Intrafollicular DA, NA and AD concentrations were significantly higher than the systemic concentrations (p < 0.05). Intrafollicular DA concentrations were higher in medium than small and large follicles (p < 0.05). Intrafollicular NA concentrations were higher in small than medium and large follicles (p < 0.05). Intrafollicular AD concentrations were higher in large than small and medium follicles (p < 0.05). Follicle diameter was significantly and negatively correlated with NA and AD (p < 0.05). A significant correlation of the same hormone concentration in FF and in systemic fluid was observed (p < 0.05). In summary, the FF can serve as an intraovarian catecholamine-storing compartment, with the ability to release neurotransmitters in a regulated way. These results provide novel insights into the neuronal nature of the follicle, suggesting the involvement of catecholamines in normal ovarian functions in mares.

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Section: Discussionmentioning

confidence: 99%