Management of Severe COVID-19 in Pregnancy

Abourida, Yassamine; Rebahi, Houssam; Oussayeh, Imane; Chichou, Hajar; Fakhir, Bouchra; Soummani, Abderraouf; Jalal, H.; Bennaoui, Fatiha; Slitine, Nadia El Idrissi; Maoulainine, Fadl Mrabih Rabou; Adib, Ahmed Rhassane El; Samkaoui, M.A.

doi:10.1155/2020/8852816

Cited by 6 publications

(7 citation statements)

References 23 publications

(29 reference statements)

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“…They did not find evidence of vertical transmission of SARS-CoV2 when the infection manifested during the third trimester of pregnancy. 4 In our study we did not find evidence of vertical transmission and the rate of preterm birth is similar in our study. Breslin et al in their study reported the first 7 confirmed cases of SARS-CoV2 infection in pregnant women presenting to a single large New York City tertiary referral centre.…”

Section: Discussionsupporting

confidence: 59%

Section: Discussionsupporting

confidence: 59%

“…Yan et al studied 116 patients to report the maternal and neonatal outcome of SARS-CoV2 infection in pregnancy. 4 Severe pneumonia was present in 8 cases (6.9%) although no maternal death was reported. Of these 8 patients, one patient had a missed spontaneous abortion in the first trimester.…”

Section: Discussionmentioning

confidence: 93%

“…During this global health crisis, pregnant women and their newborns were also significantly affected. [2][3][4] The diagnosis of COVID-19 is confirmed by reverse transcription-polymerase chain reaction (RT-PCR) assay. 5,6 The virus is transmitted mainly via respiratory droplets and/or contact and human-to-human transmission and family clustering have been reported.…”

Section: Introductionmentioning

confidence: 99%

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Effect of coronavirus-19 infection on maternal and perinatal outcome: A case control study

et al. 2021

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Introduction: Coronavirus 2019 virus infections has an impact on the obstetric population. Methods: We performed a single centre, prospective case-control study in a tertiary care centre during the first wave of the pandemic, over a period of six months. All Labouring women who were tested positive for SARS-CoV2 on the date of admission were included in the study (cases). As a control, SARS-CoV2 negative women who delivered before and after the corona virus-positive delivery were included. Results: The control group were significantly younger than the cases ( p = 0.001). The odds of spontaneous labour were observed to be significantly higher among the cases as compared to the control group ( p = 0.002). The likelihood of NICU admission was significantly higher among the cases as compared to the control group on applying Fischer exact test ( p < 0.001) Conclusion: SARS-CoV2 positive mothers are more likely to deliver neonates with feeding difficulties and requiring NICU admission, compared to SARS-CoV2 negative mothers.

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Section: Discussionsupporting

confidence: 59%

Section: Discussionsupporting

confidence: 59%

Section: Discussionmentioning

confidence: 93%

Section: Introductionmentioning

confidence: 99%

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Effect of coronavirus-19 infection on maternal and perinatal outcome: A case control study

et al. 2021

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“…Newborn deaths in this context were not directly attributable to COVID-19 infections [34,55,77,78,94,149,245]. Some have been admitted to newborn intensive care, but disease has often not been definitively attributed to viral infection [38,55,94,124,239,[245][246][247][248][249]. Newborn infection may be asymptomatic [32,58,118,136,250,251].…”

Section: Neonatal Infectionsmentioning

confidence: 99%

A Comprehensive Analysis of Maternal and Newborn Disease and Related Control for COVID-19

Cimolai

2021

SN Compr. Clin. Med.

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The maternal-fetal/newborn unit is established at risk for COVID-19 infection. This narrative review summarizes the contemporary and cumulative publications which detail maternal infection, antenatal and newborn infections, and maternal/fetal/newborn management and prevention. There is a wide spectrum of maternal disease, but the potential for severe disease albeit in a minority is confirmed. COVID-19 carries risk for preterm delivery. Pregnant females can suffer multisystem disease, and co-morbidities play a significant role in risk. Congenital infection has been supported by several anecdotal reports, but strong confirmatory data are few. No typical congenital dysmorphisms are evident. Nevertheless, placental vascular compromise must be considered a risk for the fetus during advanced maternal infections. Clinical manifestations of newborn infection have been mild to moderate and relatively uncommon. Proven antiviral therapy is of yet lacking. The mode of delivery is a medical decision that must include patient risk assessment and patient directives. Both presymptomatic and asymptomatic mothers and offspring can complicate infection control management with the potential for spread to others in several regards. In the interim, infections of the maternal-fetal-newborn unit must be taken seriously both for the disease so caused and the potential for further dissemination of disease.

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Coronavirus Disease 2019 in Pregnancy and Outcomes Among Pregnant Women and Neonates

Mark¹,

McAleese²,

Golden³

et al. 2021

Pediatric Infectious Disease Journal

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Limited data are available about the outcomes of coronavirus disease 2019 (COVID-19) during pregnancy and risk of vertical transmission in exposed neonates. We reviewed studies published February 1, 2020, through August 15, 2020, on outcomes in pregnant women with COVID-19 and neonates with perinatal exposure. Among pregnant women with COVID-19, 181 (11%) required intensive care unit admission and 123 (8%) required mechanical ventilation. There were 22 maternal deaths. Most infections occurred in the third trimester. Among women who delivered, 28% had a preterm birth, and 57% had a Caesarean section. Sixty-one (4%) of 1222 neonates with reported testing had at least 1 positive severe acute respiratory syndrome coronavirus 2 polymerase chain reaction test. The most common symptom among neonates was respiratory distress (n = 126; 21%). There were 14 neonatal deaths, one of which occurred in a neonate with positive testing. Further study of COVID-19 in pregnant women and neonates, including standardized reporting of outcomes, testing and treatment protocols, is essential to optimize maternal and neonatal care.

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Management of Severe COVID-19 in Pregnancy

Cited by 6 publications

References 23 publications

Effect of coronavirus-19 infection on maternal and perinatal outcome: A case control study

Effect of coronavirus-19 infection on maternal and perinatal outcome: A case control study

A Comprehensive Analysis of Maternal and Newborn Disease and Related Control for COVID-19

Coronavirus Disease 2019 in Pregnancy and Outcomes Among Pregnant Women and Neonates

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