was normalized in 7 out of 16 patients (44%). However, residual OSA in DS children is due to multilevel obstruction. 16,17,19 Also, we cannot ignore the craniofacial morphology of those children, such as midface hypoplasia and micrognathic jaw that could lead to narrowing of the airway. 1,2 Best et al 11 have detected the persistence of moderate to severe OSA in 40% of DS patients who underwent additional surgical procedures after adenotonsillectomy, yet, the authors achieved improvement in overall AHI. As well, Maris et al 12 obtained a success rate of 56.6% for residual OSA after adenotonsillectomy on DISE-directed treatment, anyway the authors considered an AHI < 5 to be successful.There are some limitations in our study. First, our study sample was small as we included only DS children who underwent adenotonsillectomy and still had OSA observed primarily by parents. However, parental observation is a subjective method and the disease may be missed. Second, we did not use cine-MRI for the detection of the obstructive level, as the procedure could need anesthesia in the radiology department which is an additional step in a different place. However, cine-MRI is a sensitive-noninvasive procedure that could detect obstructive lesions accurately. 19 So, a large study group is needed to assess the DISE-directed treatment option, and we need to correlate it with cine-MRI to achieve the best diagnostic method for persistent OSA after adenotonsillectomy in DS children.In conclusion, persistent OSA in DS children after adenotonsillectomy is not rare, and DISE is a useful method for detection of the cause of UAO. DISE can be done in the operating theatre as a preoperative step during induction of anesthesia. DISE-directed treatment is an effective procedure for persistent OSA in DS children who underwent adenotonsillectomy. However, residual UAO in those children may be due to many characteristic features that cause narrowing of the airway.