Management of sinus graft infection—a systematic review

Schlund, Matthias; Meeus, Joke; Politis, Constantinus; Ferri, Joël

doi:10.1016/j.ijom.2021.09.007

Cited by 9 publications

(4 citation statements)

References 40 publications

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“…As well as reinforcing adhesive and osteoinductive properties of the bone adhesive, nPDA could also be functionalized with various biomolecules, which can be adsorbed in the network of nPDA by π-π stacking, hydrogen bonding, electrostatic and hydrophobic interactions (68), and thus confer the bioactive properties to adhesives. Bone infection is a common complication of bone fractures, especially open ones (69), and may also occur following any surgery, such as osteotomies (70,71) or autograft placement (72), even when respecting strict aseptic conditions. Poor defense of bone tissue against infections, in addition to the poor penetration of systemic antibiotics into bone tissue, explains the di culties to treat bone infections ( 73) and consequent non-union.…”

Section: Discussionmentioning

confidence: 99%

In vitro and in vivo evaluation of a bio-inspired adhesive for bone fixation

Schlund

Dartus

Defrançois

et al. 2023

Preprint

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Background: Compared to metallic hardware, an effective bone adhesive can revolutionize the treatment of clinically challenging situations such as comminuted, articular and pediatric fractures. The present study aims at developing such a bio-inspired bone adhesive, based upon a modified mineral-organic adhesive with tetracalcium phosphate (TTCP) and phosphoserine (OPS) by incorporating nanoparticles of polydopamine (nPDA). Methods: The optimal formulation was screened using in vitro instrumental traction tests. Adhesion to bone, cohesion, setting time, and biomineralization of the optimized adhesive was then assessed with ex vivo instrumental and manual tests, compression tests, setting time measurement and simulated body fluid assay. Cytotoxicity was assessed by extraction test (ISO 10993-5). A new in vivo model was developed: the rat fibula was glued to the ipsilateral tibia, simulating the clinical scenario of autograft fixation under low mechanical load. Analysis was performed clinically, radiologically with micro-computed tomography and histologically (without decalcification). Results: The optimal formulation was found as 50%molTTCP/50%molOPS-2%wtnPDA with a liquid-to-powder ratio of 0.21 mL/g. This adhesive has a substantially stronger adhesive strength (1.0–1.6 MPa) to bovine cortical bone (after a 24-hour soak in a physiological saline) than the adhesive without nPDA (0.5–0.6 MPa), and is more quickly induced and has more abundant surface mineralization when immersed in simulated body fluid. Moreover, non-cytotoxicity of this adhesive was confirmed in vitro. In vivo, the TTCP/OPS-nPDA adhesive (n=7) was shown to be effective in stabilizing the graft without displacement (clinical success rate of 86% and 71% respectively at 5 and 12 weeks) compared to a sham control (0%). Significant coverage of newly formed bone was particularly observed on the surface of the adhesive, thanks to the osteoinductive property of nPDA. Conclusions: To conclude, the TTCP/OPS-nPDA adhesive fulfilled many clinical requirements for the bone fixation, and potentially could be functionalized via nPDA to offer more biological activities, e.g. anti-infection after antibiotics loading. Trial Registration: Not applicable

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Section: Discussionmentioning

confidence: 99%

In vitro and in vivo evaluation of a bio-inspired adhesive for bone fixation

Schlund

Dartus

Defrançois

et al. 2023

Preprint

View full text Add to dashboard Cite

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“…As well as reinforcing the adhesive and osteoinductive properties of the bone adhesive, nPDA could also be functionalized with various biomolecules, which can be adsorbed in the network of nPDA by π-π stacking, hydrogen bonding, and felectrostatic and hydrophobic interactions [69], thus conferring the bioactive properties to adhesives. Bone infection is a common complication of bone fractures, especially open ones [70], and may also occur following any surgery such as osteotomies [71,72] or autograft placement [73], even when respecting strict aseptic conditions. The poor defense of bone tissue against infections, in addition to the poor penetration of systemic antibiotics into bone tissue, explains the difficulties in treating bone infections [74] and consequent non-union.…”

Section: Discussionmentioning

confidence: 99%

In Vitro and In Vivo Evaluation of a Bio-Inspired Adhesive for Bone Fixation

Schlund

Dartus

Defrançois³

et al. 2023

Pharmaceutics

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Compared to metallic hardware, an effective bone adhesive can revolutionize the treatment of clinically challenging situations such as comminuted, articular, and pediatric fractures. The present study aims to develop such a bio-inspired bone adhesive, based upon a modified mineral-organic adhesive with tetracalcium phosphate (TTCP) and phosphoserine (OPS) by incorporating nanoparticles of polydopamine (nPDA). The optimal formulation, which was screened using in vitro instrumental tensile adhesion tests, was found to be 50%molTTCP/50%molOPS-2%wtnPDA with a liquid-to-powder ratio of 0.21 mL/g. This adhesive has a substantially stronger adhesive strength (1.0–1.6 MPa) to bovine cortical bone than the adhesive without nPDA (0.5–0.6 MPa). To simulate a clinical scenario of autograft fixation under low mechanical load, we presented the first in vivo model: a rat fibula glued to the tibia, on which the TTCP/OPS-nPDA adhesive (n = 7) was shown to be effective in stabilizing the graft without displacement (a clinical success rate of 86% and 71% at 5 and 12 weeks, respectively) compared to a sham control (0%). Significant coverage of newly formed bone was particularly observed on the surface of the adhesive, thanks to the osteoinductive property of nPDA. To conclude, the TTCP/OPS-nPDA adhesive fulfilled many clinical requirements for the bone fixation, and potentially could be functionalized via nPDA to offer more biological activities, e.g., anti-infection after antibiotic loading.

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“…It is generally recommended to abort the procedure if the perforation cannot be sealed intraoperatively due to the size and extent of the damage to the Schneiderian membrane 68 . The second most common complication is abnormal postoperative bleeding (14.5%), which is typically associated with damage to the posterior superior alveolar artery, 69 while the occurrence of overall postoperative infections and subacute sinusitis 70 is generally very low, at approximately 1.0% and 0.2%, respectively 23,71 . Subacute sinusitis typically manifests between 3 to 7 days after the surgical intervention.…”

Section: Treatment Alternativesmentioning

confidence: 99%

Treatment alternatives for the rehabilitation of the posterior edentulous maxilla

Ávila‐Ortiz

Végh

Mukaddam

et al. 2023

Periodontology 2000

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Rehabilitation of the edentulous maxilla with implant‐supported fixed dental prostheses can represent a significant clinical challenge due to limited bone availability and surgical access, among other factors. This review addresses several treatment options to replace missing teeth in posterior maxillary segments, namely the placement of standard implants in conjunction with maxillary sinus floor augmentation, short implants, tilted implants, and distal cantilever extensions. Pertinent technical information and a concise summary of relevant evidence on the reported outcomes of these different therapeutic approaches are presented, along with a set of clinical guidelines to facilitate decision‐making processes and optimize the outcomes of therapy.

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Management of sinus graft infection—a systematic review

Cited by 9 publications

References 40 publications

In vitro and in vivo evaluation of a bio-inspired adhesive for bone fixation

In vitro and in vivo evaluation of a bio-inspired adhesive for bone fixation

In Vitro and In Vivo Evaluation of a Bio-Inspired Adhesive for Bone Fixation

Treatment alternatives for the rehabilitation of the posterior edentulous maxilla

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