Management of Status Asthmaticus

Ibrahim, Ameer F.; Blohm, Eike; Hammad, H. A. M.

doi:10.1007/s40138-015-0081-y

Cited by 2 publications

(2 citation statements)

References 104 publications

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“…N-acetylcysteine causes side effects such as vomiting, stomatitis, nausea, fever, drowsiness, clamminess, chest tightness, bronchoconstriction and rhinorrhea in some patients (5). Significant airflow limitation is unpredictable and uncommon in asthmatic bronchitis patients or patients with bronchial asthma complicated by bronchitis (6). In some countries of Europe N-acetylcysteine used to improve symptoms and decrease frequency of exacerbations in chronic bronchitis.…”

Section: Introductionmentioning

confidence: 99%

Role of N-Acetylcysteine in Clearance of Secretions in Mechanical Ventilated Patients

2019

JMPB

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Objective:To determine the role of nebulized N-acetylcysteine in mechanical ventilation in clearing the airway of these patients Study Design: A Randomized Control Trial. Place and Duration of Study:Material and Methods: In this project total 50 patients were enrolled by consecutive sampling who remained on mechanical ventilation for more than 24 hours and were between ages 15 to 80 years old. Written consent of this project was taken from relative of each patient. These patients were divided into two groups by lottery method into case and control. The case group received 2 ml of NAC 20% with 8 ml normal saline 3 times a day for 1 day. The control group only received 10 ml normal saline via their nebulizers 3 times a day at 8 AM, 2 PM, and 9 PM. Data was collected and was analyzed. SPSS 22 was used for this purpose. All numerical variables of this research such as mean FiO2, mean peak and plateau pressure of airway, mean blood pressure, mean age and importantly mean density of secretions were calculated. In these values t test was applied and p value was calculated. If it was less than .005, then it was considered significant. Similarly, qualitative data such as type of disease were calculated in percentage and chi square test was used to check the significance. Results:The mean O2 saturation of baseline, 12 hours and 24 hours of the controls was 93.84±2.28, 94.27±2.33 and 94.08±1.81 respectively. The mean peak airway pressure of baseline, 12 hours and 24 hours of the controls was 23.16±3.49, 25.38±8.86 and 24.01±4.91 respectively. The mean plateau airway pressure of baseline, 12 hours and 24 hours of the controls was 19.04±7.79, 21.37±4.86 and 21.85±8.93 respectively. The mean secretion density of baseline, 12 hours and 24 hours of the controls was 1.04±0.024, 1.05±0.03 and 1.03±0.002 respectively. While, the mean O2 saturation of baseline, 12 hours and 24 hours of the cases was 93.08±2.37, 94.61±2.56 and 94.11±2.34 respectively. The mean peak airway pressure of baseline, 12 hours and 24 hours of the cases was 26.58±5.81, 23.81±8.28 and 24.34±6.15 respectively. The mean plateau airway pressure of baseline, 12 hours and 24 hours of the cases was 21.88±78.01, 24.88±6.67 and 23.51±7.55 respectively. The mean secretion density of baseline, 12 hours and 24 hours of the cases was 1.01±0.021, 1.08±0.022 and 1.008±0.0195 respectively. The differences were statistically insignificant. P-value ≤ 0.05 is considered as significant.Conclusion: It is concluded from our observations that use of N-acetylcysteine in patients on mechanical ventilation is very effective in clearance of secretion and to maintain airway clear.

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Section: Introductionmentioning

confidence: 99%

Role of N-Acetylcysteine in Clearance of Secretions in Mechanical Ventilated Patients

2019

JMPB

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“…Mucous plugs those are retained secretions in tracheobronchial tree are often observed in patients who are mechanically ventilated due to depressed mucociliary clearance, cough reflex and more production of sputum (2). The average annual relative humidity showed significant increase over the years and ranged from 58 to 71% with mean value of 64% in Indian Punjab (3) 6 predispose patients to mucous plugs, causing severe morbidity and even mortality. Therapy with mucolytic drugs can be used to reduce bacterial load, improve lung function, more clearance of sputum from airway and decreasing viscosity of airway.…”

Section: Introductionmentioning

confidence: 99%

Role of N-Acetylcysteine in Clearance of Secretions in Mechanical Ventilated Patients

2019

JMPB

View full text Add to dashboard Cite

Objective: to determine the role of nebulized N-acetylcysteine in mechanical ventilation in clearing the airway of these patients. Study Design: A Randomized Control Trial. Place and Duration .Methods: In this project total 50 patients were enrolled by consecutive sampling who remained on mechanical ventilation for more than 24 hours and were between age 15 to 80 years old. Written consent of this project was taken from relative of each patient. These patients were divided into two groups by lottery method into case and control. The case group received 2 ml of NAC 20% with 8 ml normal saline 3 times a day for 1 day. The control group only received 10 ml normal saline via their nebulizers 3 times a day at 8 AM, 2 PM, and 9 PM. Data was collected and was analyzed. SPSS 22 was used for this purpose. All numerical variables of this research such as mean FiO2, mean peak and plateau pressure of airway, mean blood pressure, mean age and importantly mean density of secretions were calculated. In these values t test was applied and p value was calculated. If it was less than .005, then it was considered significant. Similarly, qualitative data such as type of disease were calculated in percentage and chi square test was used to check the significance. Results: The mean O2 saturation of baseline, 12 hours and 24 hours of the controls was 93.84±2.28, 94.27±2.33 and 94.08±1.81 respectively. The mean peak airway pressure of baseline, 12 hours and 24 hours of the controls was 23.16±3.49, 25.38±8.86 and 24.01±4.91 respectively. The mean plateau airway pressure of baseline, 12 hours and 24 hours of the controls was 19.04±7.79, 21.37±4.86 and 21.85±8.93 respectively. The mean secretion density of baseline, 12 hours and 24 hours of the controls was 1.04±0.024, 1.05±0.03 and 1.03±0.002 respectively. While, the mean O2 saturation of baseline, 12 hours and 24 hours of the cases was 93.08±2.37, 94.61±2.56 and 94.11±2.34 respectively. The mean peak airway pressure of baseline, 12 hours and 24 hours of the cases was 26.58±5.81, 23.81±8.28 and 24.34±6.15 respectively. The mean plateau airway pressure of baseline, 12 hours and 24 hours of the cases was 21.88±78.01, 24.88±6.67 and 23.51±7.55 respectively. The mean secretion density of baseline, 12 hours and 24 hours of the cases was 1.01±0.021, 1.08±0.022 and 1.008±0.0195 respectively. The differences were statistically insignificant. P-value ≤ 0.05 is considered as significant. Conclusion: It is concluded from our observations that use of N-acetylcysteine in patients on mechanical ventilation is very effective in clearance of secretion and to maintain airway clear.

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Management of Status Asthmaticus

Cited by 2 publications

References 104 publications

Role of N-Acetylcysteine in Clearance of Secretions in Mechanical Ventilated Patients

Role of N-Acetylcysteine in Clearance of Secretions in Mechanical Ventilated Patients

Role of N-Acetylcysteine in Clearance of Secretions in Mechanical Ventilated Patients

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