Objective: Identify the factors affecting the non-traumatic intestinal perforations peritonitis outcome. Methods: This was a retrospective study over a period of 30 months (1 st January 2014-30 th June 2016), which took place in four hospitals in northern Benin, including three district hospitals and one teaching hospital. The study population consisted of patients operated for generalized acute peritonitis. The inclusion criteria were: peroperative confirmation of the non-traumatic ileal perforation and the existence of a complete medical record in relation to the variables studied. Results: We collected 121 cases of non-traumatic ileal perforation peritonitis with a total of 447 cases of generalized acute peritonitis; the non traumatic ileal perforation peritonitis frequency was 27.1%. Ninety-nine files met the inclusion criteria. The mean age was 17 ± 12 years with extremes of 2 and 60 years. The sex ratio was 2.4. The predictive factors were: age (p 0.00), consultation time (p 0.03), surgical time (p 0.02), amount of peritoneal fluid (p 0.001), perforation number (p 0.0009), surgical technique (p 0.0003) and postoperative complications such as digestive fistula (p 0.001) and postoperative peritonitis (p 0.04). Conclusions: At the end of our study, the factors of bad prognosis identified were the age, the time of consultation, the time of surgery, the quantity of peritoneal fluid. Some postoperative complications may cause death.