Management of the pediatric patient with asthma and obesity

Averill, Samantha H.; Forno, Erick

doi:10.1016/j.anai.2023.10.001

Cited by 8 publications

(2 citation statements)

References 113 publications

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“…The connection among obesity, asthma, and OSA is complex and multifaceted, potentially exacerbating each other. Obesity represents a significant risk factor for both asthma [74] and OSA. Finally, obesity and SDB often coexist, with inflammation associated with obesity potentially influencing asthma control and the reciprocal relationship between OSA and asthma or AR [58].…”

Section: Down Syndrome and Immunitymentioning

confidence: 99%

“…Moving on to obesity, asthma, and OSA, epidemiological studies firmly establish a link between obesity and asthma in children [63,64], with obesity contributing to a persistent low-level inflammatory state [63]. OSA is prevalent among children with asthma, suggesting a bidirectional relationship between these two conditions [58,74]. The intricate interplay among obesity, asthma, and OSA exacerbates respiratory symptoms, highlighting the need for further research to understand underlying factors better.…”

Section: Comparison Analysis Of the Reviewed Studiesmentioning

confidence: 99%

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Exploring the Complex Interplay of Obesity, Allergic Diseases, and Sleep-Disordered Breathing in Children

Voltan,

Concer,

Pecoraro

et al. 2024

Children

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This narrative review study investigates the correlations between obesity, allergies, and sleep-disordered breathing in pediatric populations. Searches for pertinent articles were conducted on the Medline PubMed Advanced Search Builder, Scopus, and Web of Science databases from unlimited to April 2024. Sleep-disordered breathing causes repeated upper airway obstructions, leading to apneas and restless sleep. Childhood obesity, which affects around 20% of children, is often associated with sleep-disordered breathing and allergies such as asthma and allergic rhinitis. It is distinguished between diet-induced obesity (resulting from excess of diet and physical inactivity) and genetic obesity (such as is seen in Down syndrome and Prader–Willi syndrome). In children with diet-induced obesity, chronic inflammation linked to weight can worsen allergies and increase the risk and severity of asthma and rhinitis. Furthermore, the nasal congestion typical of rhinitis can contribute to upper respiratory tract obstruction and obstructive sleep apnea. A vicious circle is created between asthma and sleep-disordered breathing: uncontrolled asthma and sleep-disordered breathing can worsen each other. In children with genetic obesity, despite alterations in the immune system, fewer allergies are observed compared to the broader population. The causes of this reduced allergenicity are unclear but probably involve genetic, immunological, and environmental factors. Additional research is necessary to elucidate the underlying mechanisms. The present narrative review study emphasizes the importance of jointly evaluating and managing allergies, obesity, and obstructive sleep apnea in children considering their close interconnection.

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Section: Down Syndrome and Immunitymentioning

confidence: 99%