Management of the Thyroid Gland in Papillary Carcinoma of the Thyroglossal Cyst: A Case Report

George, Philip; Mani, Suresh; Telugu, Ramesh Babu; Michael, Rajiv Charles

doi:10.31729/jnma.5027

Cited by 4 publications

(8 citation statements)

References 6 publications

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“…The TCD is considered the most frequent central cervical benign lesion; it is present in 7% of the population. 1,3,6 Its origin lies in the cystic expansion of the remaining epithelium of the thyroglossal duct, with the possibility of associating ectopic thyroid tissue adhered to the cyst wall in up to 50% of cases. 7 Cases of malignant degeneration into carcinomas have been reported in up to 1% of patients with TCD, with a greater tendency to affect women in the fourth decade of life.…”

Section: Discussionmentioning

confidence: 99%

“…TDCCa is usually asymptomatic at the beginning, and its definitive diagnosis is generally incidental after surgical excision and anatomopathological analysis. [5][6][7] The most frequent histological type of TDCCa is papillary carcinoma (80%). 1,2 The simultaneous presentation of papillary TDCCa with papillary thyroid carcinoma does not have a specific prevalence due to how infrequent it is in clinical practice.…”

Section: Introductionmentioning

confidence: 99%

“…1,2 The simultaneous presentation of papillary TDCCa with papillary thyroid carcinoma does not have a specific prevalence due to how infrequent it is in clinical practice. 4,6 The treatment of papillary TDCCa is generally surgical, using the Sistrunk technique. 6 Total or partial hyroidectomy is associated when the patients have associated risk factors such as age (over 45 years) and the size of the lesion, among others.…”

Section: Introductionmentioning

confidence: 99%

“…4,6 The treatment of papillary TDCCa is generally surgical, using the Sistrunk technique. 6 Total or partial hyroidectomy is associated when the patients have associated risk factors such as age (over 45 years) and the size of the lesion, among others. 8 The objective of this article is to present a case report of TDCa associated with papillary thyroid carcinoma, describe the diagnostic steps to decide the appropriate treatment, and discuss according to the actual published literature.…”

Section: Introductionmentioning

confidence: 99%

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Papillary carcinoma affecting a lateral thyroglossal cyst duct and thyroid: a case report

Dávila,

Villaroel,

Coello

et al. 2023

JOENTR

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Papillary carcinoma affecting a lateral thyroglossal cyst duct and thyroid: a case report

Dávila,

Villaroel,

Coello

et al. 2023

JOENTR

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“…In addition to the specified criteria, indications for this treatment are male gender, distant metastases, and tumor invasion into the surrounding tissues. Postoperative ablation with radioactive iodine and suppressive therapy with levothyroxine is considered the best treatment before starting follow-up [8].…”

Section: Figure 1 -Pathohistological Examination Of the Tgdc Showed A...mentioning

confidence: 99%

Papillary Carcinoma of the Thyroglossal Duct Cyst: A Case Report

Duzhyi

Kononenko

Moskalenko

et al. 2023

EUMJ

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Introduction. Thyroglossal duct cysts (TGDCs) can be diagnosed at any age. They are most common in women aged 30–40. Cysts can become malignant in 1% of patients. As a result, a very rare tumor – TGDC carcinoma ¬– develops. Some oncologists believe it is sufficient to perform surgery using the Sistrunk procedure. Other scientists insist on performing the Sistrunk procedure followed by thyroidectomy, lymph node dissection, and radioactive iodine ablation. In this report, we would like to share our successful experience in treating a patient with papillary carcinoma of PCOS. Case report. A 47-year-old woman had persistent midline neck swelling for three years. This lesion was completely asymptomatic. The patient had no cases of head and neck irradiation or a family history of thyroid gland diseases. Physical examination revealed a solid, movable, smooth mass measuring 6.0 × 5.0 × 4.0 cm on the anterior surface of the neck. The thyroid gland was of normal size, without nodules. Lymph nodes of the neck were not enlargement. During sticking out the tongue and swallowing, the tumor moved upwards. Neck ultrasound, CT scan, and fine-needle aspiration biopsy confirmed the presence of TGDC papillary carcinoma. All laboratory results, including thyroid hormones, were within normal ranges. The patient underwent the Sistrunk procedure, total thyroidectomy with central lymph node dissection, radioactive iodine ablation, and suppression of thyroid function with levothyroxine. The patient's follow-up period has been currently 110 months. There were no signs of relapse. Discussion. The etiology of the malignant transformation of the TGDC remains unknown. One of the main theories is the spontaneous development of ectopic thyroid tissue located in the cyst walls. Ultrasound, CT, and MRI are considered sufficiently informative methods. A fine-needle aspiration biopsy confirms TGDC carcinoma in 53% of patients before surgery. Virtually all patients with TGDC carcinomas undergo the Sistrunk procedure. In addition, some of them perform a total thyroidectomy. Criteria for total thyroidectomy are age older than 45 years, history of neck irradiation, tumor size greater than 4 cm, presence of regional metastases, and thyroid gland dysfunction. Postoperative radioiodine ablation and suppressive levothyroxine therapy are considered the best treatment before the start of the follow-up period. Conclusions. The treatment of patients with TGDC carcinomas should be personalized. Determining criteria should be the patient's age, gender, condition of the thyroid gland and regional lymph nodes, size of the primary tumor, resection margins, invasion of the tumor into the surrounding tissues, and family history of thyroid diseases.

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Clinical Observation and Analysis of Thyroglossal Duct Cyst Carcinoma: A Report of 5 Cases

Lei,

Chen,

Pang

et al. 2023

Ear Nose Throat J

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Thyroglossal duct cyst carcinoma (TGDCCa) is a rare condition with only approximately 300 cases reported to date. There is a lack of comprehensive reporting on its clinical manifestations, ultrasound, contrast-enhanced computed tomography, magnetic resonance imaging (MRI) features, immunophenotyping, procedure, and prognosis following modified Sistrunk’s procedure. This study aimed to address these gaps by analyzing and summarizing the clinical features of 5 cases of papillary carcinoma arising in thyroglossal duct cysts (TGDC). Five patients with papillary carcinoma in TGDC treated by modified Sistrunk’s procedure were included. Their clinical manifestation, physical examination findings, iconography, pathological findings, treatment, and outcomes were analyzed in aiding the diagnosis and treatment of TGDCCa. Immunohistochemistry was used to confirm the papillary carcinoma subtype. The BRAFV600E mutation was detected in 2 patients. No evidence of cancer recurrence, distant metastases, and malignant changes in the thyroid was found after a mean follow-up of 29.8 months. The management of TGDCCa with papillary carcinoma in low-risk patients can be accomplished by performing a modified Sistrunk’s procedure along with a regular follow-up imaging of the thyroid and neck. Although postoperative pathological diagnosis is the gold standard for diagnosis, it is equally crucial to comprehend the clinical manifestations and auxiliary diagnostic techniques before surgical intervention.

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Management of the Thyroid Gland in Papillary Carcinoma of the Thyroglossal Cyst: A Case Report

Cited by 4 publications

References 6 publications

Papillary carcinoma affecting a lateral thyroglossal cyst duct and thyroid: a case report

Papillary carcinoma affecting a lateral thyroglossal cyst duct and thyroid: a case report

Papillary Carcinoma of the Thyroglossal Duct Cyst: A Case Report

Clinical Observation and Analysis of Thyroglossal Duct Cyst Carcinoma: A Report of 5 Cases

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