Management of Thyroid Follicular Proliferation: An Ultrasound-Based Malignancy Score to Opt for Surgical or Conservative Treatment

Pompili, G; Tresoldi, Silvia; Primolevo, Alessandra; Pasquale, Loredana De; Leo, Giovanni Di; Cornalba, Gianpaolo

doi:10.1016/j.ultrasmedbio.2013.02.464

Cited by 17 publications

(23 citation statements)

References 18 publications

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“…Previous studies have identified certain ultrasonic features that predict follicular cancer 34 35 . The present study indicates that there are significant differences in the EI values between follicular adenoma and carcinoma.…”

Section: Discussionmentioning

confidence: 99%

Quantitative analysis of echogenicity for patients with thyroid nodules

Chen

et al. 2016

Sci Rep

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Hypoechogenicity has been described qualitatively and is potentially subject to intra- and inter-observer variability. The aim of this study was to clarify whether quantitative echoic indexes (EIs) are useful for the detection of malignant thyroid nodules. Overall, 333 participants with 411 nodules were included in the final analysis. Quantification of echogenicity was performed using commercial software (AmCAD-UT; AmCad BioMed, Taiwan). The coordinates of three defined regions, the nodule, thyroid parenchyma, and strap muscle regions, were recorded in the database separately for subsequent analysis. And the results showed that ultrasound echogenicity (US-E), as assessed by clinicians, defined hypoechogenicity as an independent factor for malignancy. The EI, adjusted EI (EIN-T; EIN-M) and automatic EI(N-R)/R values between benign and malignant nodules were all significantly different, with lower values for malignant nodules. All of the EIs showed similar percentages of sensitivity and specificity and had better accuracies than US-E. In conclusion, the proposed quantitative EI seems more promising to constitute an important advancement than the conventional qualitative US-E in allowing for a more reliable distinction between benign and malignant thyroid nodules.

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Section: Discussionmentioning

confidence: 99%

Quantitative analysis of echogenicity for patients with thyroid nodules

Chen

et al. 2016

Sci Rep

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“…However, sonographic features were not adequate for distinguishing high‐risk FTC from follicular adenoma or low‐risk to intermediate‐risk FTC . Few studies have reported on the ability of US to determine the characteristics of follicular‐pattern lesions that have more serious prognosis; however, studies regarding imaging findings for predicting distant metastasis are yet to be conducted …”

Section: Introductionmentioning

confidence: 99%

Prediction of follicular thyroid carcinoma associated with distant metastasis in the preoperative and postoperative model

et al. 2019

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Background Only clinicopathological findings are reported for predicting follicular thyroid carcinoma (FTC) associated with distant metastasis, and preoperative ultrasound (US) findings are unknown. Methods Associations between distant metastases of FTC and predicting factors were evaluated by using logistic regression analysis in the preoperative and postoperative models. Results Distant metastasis was present in 37 (11.5%) of the 321 patients with FTC. In the preoperative model, independent predictors of distant metastasis were age, marked hypoechogenicity, nodule‐in‐nodule appearance, and rim calcification on US. Postoperative predictors were marked hypoechogenicity, rim calcification, and widely invasive histology. Sensitivities, specificities, and the area under the curves for predicting distant metastasis were 86.5%, 80.3%, and 0.889 on preoperative status and 86.5%, 78.5%, and 0.908 on postoperative status. Although not statistically significant, all four patients with gross extrathyroidal extension had metastasis. Conclusion Age, ultrasound features, and widely invasive histology allow preoperative and postoperative prediction of FTC associated with distant metastasis.

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“…Около 20-30% случаев относятся к классам iii-iV по системе веthesda [17]. Такие варианты интерпретации как атипия неясного генеза, фолликулярная неоплазия и подозрение на злокачественность ассоциированы с риском малигнизации соответственно от 15 до 75% [16,19]. исторически, руководство по выбору лечебной тактики во всем мире рекомендует проведение пациентам с неопределенными результатами цитологии выполнение оперативного вмешательства для получения точного патогистологического диагноза [2,7].…”

Section: узи тапб и цитологическая диагностика рщжunclassified

“…критериями, которые позволяют исключить диагноз «неинвазивный инкапусулированный фолликулярный вариант прЩж» являются: «настоящие» папиллы >1%, наличие псаммомных телец, инфильтрация границ опухоли, некротические изменения в опухоли, высокая митотическая активность клеток, структурные признаки других вариантов прЩж [13]. [15,16]…”

Section: Introductionunclassified