Management of traumatic segmental bone loss using linear rail system, our experience at the University of Maiduguri Teaching Hospital, Maiduguri, Nigeria

Strontium Ranelate Reduces Duration of Consolidation Phase in Distraction Osteogenesis: 2 Case Reports

“…However, it was not until 1950 that this technique widespread through the works of Ilizarov. The common indications for distraction osteogenesis are open fractures, bone resection due to chronic osteomyelitis or infected non-union, large bone loss at initial time of trauma, limb length discrepancies and bony deformities [1][2][3][4][5][6][7]16]. It is often a limb salvage procedure but also has a role in cosmetic lengthening in short statures [2,9].…”

“…Distraction osteogenesis can eliminate the need for bone grafts. Other known methods to treat large bone deficiencies are allografts, synthetic bone grafts, membrane induction technique or also known as Masquelet technique, cortical strut grafting, or vascularised bone grafting [2][3][4][5][6]8,9]. Some literatures also have mentioned acute shortening followed by bone lengthening later [7].…”

“…Distraction phase is the interval between onset of distraction to the time of docking or end of transport. The normal distraction rate is 0.25mm four times a day (1mm/day) [2,3,9]. During distraction, regenerate bone arises between the entire cross-sections of each distracted bone surface with a central radiolucent fibrous interzone comprising of type I collagen.…”

“…Strontium nucleus is almost similar in size to that of calcium, the body easily absorbs it, incorporating it into the bones and tooth enamel instead of calcium It is a drug used in treatment of osteoporosis and it both increases deposition of new bone by osteoblasts and reduces the resorption of bone by osteoclasts [11,1,2,14]. Due to its both anabolic and anti-catabolic activity towards bone healing it is known as dual action bone agents (DABA) [11,1,2,14]. It acts through RANK/RANKL/OPG system [11].…”

“…Distraction osteogenesisis a debilitating and time consuming procedure in orthopedics. The common indications for distraction osteogenesis are open fractures, non-union, bone resection due to chronic osteomyelitis or large bone loss at initial time of trauma [1][2][3][4][5][6][7][8]. It is often a limb salvage procedure but also has a role in cosmetic lengthening in short statures [3,9].Other known methods to treat large bone deficiencies are bone grafting (autograft, allograft or synthetic), membrane induction technique or also known as Masquelet technique, cortical strut grafting, or vascularised bone grafting [1,3,[8][9][10].…”