Management of Treatment-Related Intermittent Partial Small Bowel Obstruction: The Use of Octreotide

Myers, Jeff; Tamber, Anoo; Farhadian, M.

doi:10.1016/j.jpainsymman.2009.11.309

Cited by 5 publications

(3 citation statements)

References 10 publications

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“…5,34,[40][41][42][43] A recent case report found octreotide helpful in resolving symptoms of partial bowel obstruction that were unresponsive to standard measures. 44 Octreotide is well tolerated and reduces the time patients require a nasogastric tube without significantly worsening xerostomia. High cost limits its use in American hospice care due to the Medicare capitated system of reimbursement for drugs and services, and as a result it is a second-tier drug despite evidence of its efficacy.…”

Section: Which Drugs Can I Use For Abdominal Pain?mentioning

confidence: 99%

Malignant bowel obstruction: Individualized treatment near the end of life

Soriano

Davis

2011

CCJM

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Section: Which Drugs Can I Use For Abdominal Pain?mentioning

confidence: 99%

Malignant bowel obstruction: Individualized treatment near the end of life

Soriano

Davis

2011

CCJM

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“…Medical therapies have centered on the use of pro-motility, anti-secretory, and anti cholinergic agents to medically reduce the intraluminal pressure by reducing the production of intestinal secretions and to assist intestinal peristalsis [6,7]. Several authors have focused on the use of Octreotide, an inject able medication, along with corticosteroids and anti-emetics for relief of symptoms of FIO [8,9]. However the sample size in these studies wasn't adequate and Octreotide being an inject able medication was not outpatient friendly.…”

Section: Introductionmentioning

confidence: 99%

The Effect of a Medical Decompression Protocol on the Use of Antiemetics, Nasogastric Tube Usage and Diet Advance in Late Stage Cancer Patients With Functional Intestinal Obstruction

Bhati¹,

Shrivastava²

2020

ijsr

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Background: At the end of life, many cancer patients suffer from a syndrome that simulates classic small bowel obstruction. The traditional approach to intestinal obstruction is relief of pressure in the gastrointestinal tract using mechanical methods. The Medical Decompression(MD) protocol is a non-invasive pharmacologic approach for this problem that is easy and economical. Methods: The study was done in a academic institution of central India from April 2019 to October 2019. It included 21 cases based on the inclusion and exclusion criteria. Data regarding demographics, cancer diagnosis, existing drug history and diet history was collected and the sample was randomly divided into two groups: one received medical decompression and the other didn’t. The data was compared using t-tests on the outcome variable days to advanced diet. Results: Out of 21 cases, 43% were males whereas 57% were females with a mean age of 66 years. About 30% of these had a pre-inserted NG tube. Around 19% of these were already on a clear liquid diet. Most men had colon cancer whereas most females had ovarian cancer. A mean of 1.1 doses and 3.8 days was taken to advance the diet. There was a statistically significant difference between the MD and the non MD group. Conclusions: A pharmacologic method such as MD is strongly useful as first line treatments for the functional intestinal obstruction syndrome and indeed be considered as adjuncts to allow the removal of invasive mechanical interventions in the end of life patient.

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“…Several authors have focused on the use of Octreotide, an inject able medication, along with corticosteroids and anti-emetics for relief of symptoms of FIO [8,9]. These reports regarding the effectiveness of various regimens including Octreotide had 15, 1, and 4 subjects respectively.…”

Section: Introductionmentioning

confidence: 99%

The Effect Of A Medical Decompression Protocol On The Use Of Antiemetics, Nasogastric Tube Usage And Diet Advance In Late Stage Cancer Patients With Functional Intestinal Obstruction

Calves¹,

Saraceno²,

C³

et al. 2017

PMCOA

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At the end of life, many patients suffer from a syndrome that simulates classic small bowel obstruction. The traditional approach to intestinal obstruction is relief of pressure in the gastrointestinal tract using mechanical methods such as naso-gastric tube insertion and suctioning. This relieves the distension of the hollow organs and thus the nausea.. Pharmacologic methods are also used in the care of these patients, however, there is debate as to which agents to use and when to use them. The Medical Decompression protocol is a non-invasive pharmacologic approach to this problem. It brings with it ease and economy of delivery, the ability to administer it in intravenous as well as oral form, and is a multi-agent protocol of tried and true drugs used at the end of life: 1/2 Metoclopramide, Dexamethasone, Diphenhydramine, and Pantoprazole Prior to initiating this intervention, patients and their families are educated and are aware that this intervention is most likely a temporary measure aimed at symptom relief, as well as an attempt to improve quality of life. Our sample contained 42 males and 62 females, with an average age of about 70 years. About 51% of participants received MD (n = 53). Results indicated that there was a statistically significant difference between the two groups related to days to progress diet. We propose that a pharmacologic method such as MD is strongly considered as first line treatments for the functional intestinal obstruction syndrome and indeed be considered as adjuncts to allow the removal of invasive mechanical interventions in the end of life patient.

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Management of Treatment-Related Intermittent Partial Small Bowel Obstruction: The Use of Octreotide

Cited by 5 publications

References 10 publications

Malignant bowel obstruction: Individualized treatment near the end of life

Malignant bowel obstruction: Individualized treatment near the end of life

The Effect of a Medical Decompression Protocol on the Use of Antiemetics, Nasogastric Tube Usage and Diet Advance in Late Stage Cancer Patients With Functional Intestinal Obstruction

The Effect Of A Medical Decompression Protocol On The Use Of Antiemetics, Nasogastric Tube Usage And Diet Advance In Late Stage Cancer Patients With Functional Intestinal Obstruction

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