Management of urinary tract infections in the era of antimicrobial resistance

Pothoven, Ria

doi:10.33393/dti.2023.2660

Cited by 4 publications

(4 citation statements)

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“…Indeed, the empiric choice of the most appropriate antibiotic agent for UTI requires updated knowledge of the causes of the infection and the status of antimicrobial resistance among uropathogens. The findings are also crucial for developing guidelines for the empiric antibiotic treatment of UTI [ 1 , 3 , 11 ]. However, as data on the causative uropathogens and their antimicrobial susceptibility patterns vary by location and time, updated local data are of major importance [ 3 , 10 , 15 ].…”

Section: Discussionmentioning

confidence: 99%

“…The findings are also crucial for developing guidelines for the empiric antibiotic treatment of UTI [ 1 , 3 , 11 ]. However, as data on the causative uropathogens and their antimicrobial susceptibility patterns vary by location and time, updated local data are of major importance [ 3 , 10 , 15 ].…”

Section: Discussionmentioning

confidence: 99%

“…The resistance profiles of uropathogens to antimicrobials are region- and time-dependent. Therefore, it is prudent to test the trends of antibiotic-resistant uropathogens periodically and locally, to update guidelines and provide patients with the most appropriate antibacterial therapy for UTI [ 3 , 11 , 40 , 41 , 42 ].…”

Section: Discussionmentioning

confidence: 99%

“…Urinary tract infection (UTI) is one of the most common bacterial infections during childhood [ 1 , 2 , 3 ]. The prevalence of UTIs varies according to age, gender, and geographical location.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Pathogens Causing Pediatric Community Acquired Urinary Tract Infections and Their Increasing Antimicrobial Resistance: A Nationwide Study

Shkalim Zemer,

Ashkenazi,

Levinsky

et al. 2024

Pathogens

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Urinary tract infections (UTIs) in childhood are common and are associated with considerable acute morbidity and long-term complications. The need for updated data to optimize empiric antibiotic therapy is crucial. We aimed to investigate the pathogens causing pediatric community acquired UTIs, their correlation with demographic characteristics, and trends in their antimicrobial resistance. This nationwide cross-sectional study included all 53,203 children (<18 years) diagnosed with UTI in community outpatient clinics in the following selected years: 2007, 2011, 2015, 2019 and 2021. Escherichia coli (E. coli) (82.1%) was the most common uropathogen, followed by Enterobacter, Klebsiella, Proteus, Pseudomonas, and Enterococcus species. The bacterial distribution displayed statistically significant (p < 0.0001) gender- and sector-specific patterns with a higher relative prevalence of non-E. coli UTI in Jewish and males. The rate of extended-spectrum beta-lactamase-positive E. coli increased substantially and significantly (p < 0.001) from only 6.1% in 2007 to 25.4% in 2021. Most non-E. coli uropathogens exhibited resistance to commonly used empiric antibiotics for UTIs in children. These findings are significant in guiding optimal empiric antibiotic treatment for pediatric community acquired UTIs. The resistance of uropathogens to antimicrobials is region- and time-dependent. Therefore, the periodic and local assessment of antibiotic resistance trends is essential to update guidelines and provide the most appropriate antibacterial therapy for children with UTIs.

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