Management of venous thromboembolism

Moerloose, Philippe de; Samama, Charles Marc; Motte, Serge

doi:10.1007/bf03022255

Cited by 3 publications

(2 citation statements)

References 62 publications

(43 reference statements)

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“…The 2008 ACCP guidelines recommend parenteral anticoagulant treatment ≥5 days and the achievement an INR ≥2.0 for ≥24 hours before stopping parenteral anticoagulation because randomized trials of VTE treatment often used heparin therapy for a minimum duration of five days [ 1 , 27 – 29 ]. Moreover, there is evidence from animal studies that VKA require several days before developing a therapeutic antithrombotic effect [ 30 , 31 ].…”

Section: Discussionmentioning

confidence: 99%

Anticoagulation Management Practices and Outcomes in Elderly Patients with Acute Venous Thromboembolism: A Clinical Research Study

et al. 2016

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Whether anticoagulation management practices are associated with improved outcomes in elderly patients with acute venous thromboembolism (VTE) is uncertain. Thus, we aimed to examine whether practices recommended by the American College of Chest Physicians guidelines are associated with outcomes in elderly patients with VTE. We studied 991 patients aged ≥65 years with acute VTE in a Swiss prospective multicenter cohort study and assessed the adherence to four management practices: parenteral anticoagulation ≥5 days, INR ≥2.0 for ≥24 hours before stopping parenteral anticoagulation, early start with vitamin K antagonists (VKA) ≤24 hours of VTE diagnosis, and the use of low-molecular-weight heparin (LMWH) or fondaparinux. The outcomes were all-cause mortality, VTE recurrence, and major bleeding at 6 months, and the length of hospital stay (LOS). We used Cox regression and lognormal survival models, adjusting for patient characteristics. Overall, 9% of patients died, 3% had VTE recurrence, and 7% major bleeding. Early start with VKA was associated with a lower risk of major bleeding (adjusted hazard ratio 0.37, 95% CI 0.20–0.71). Early start with VKA (adjusted time ratio [TR] 0.77, 95% CI 0.69–0.86) and use of LMWH/fondaparinux (adjusted TR 0.87, 95% CI 0.78–0.97) were associated with a shorter LOS. An INR ≥2.0 for ≥24 hours before stopping parenteral anticoagulants was associated with a longer LOS (adjusted TR 1.2, 95% CI 1.08–1.33). In elderly patients with VTE, the adherence to recommended anticoagulation management practices showed mixed results. In conclusion, only early start with VKA and use of parenteral LMWH/fondaparinux were associated with better outcomes.

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Section: Discussionmentioning

confidence: 99%

Anticoagulation Management Practices and Outcomes in Elderly Patients with Acute Venous Thromboembolism: A Clinical Research Study

et al. 2016

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“…36 Caution during treatment with heparin is necessary in combined antiplatelet therapy, serious renal insufficiency (creatinine clearance <30 mL/min), uncontrolled arterial hypertension (blood pressure >180/ 110 mmHg), and in patients weighing <40 kg. 37 In the case of serious renal insufficiency, doses of heparin can be monitored using plasmatic anti-Xa antibodies. If LMWH is not accessible, it is possible to carry on prophylaxis with unfractionated heparin 2-3 times s.c. a day.…”

Section: Discussionmentioning

confidence: 99%

Assessment of risk of venous thromboembolism and its possible prevention in psychiatric patients

Malý¹,

Masopust

Hosák

et al. 2008

Psychiatry Clin Neurosci

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Aims:The aim of the present study was to compile a specific algorithm of prevention of venous thromboembolism in hospitalized psychiatric patients because this specific issue has not been addressed sufficiently in the literature. Methods:The computer database MEDLINE was searched using key words (schizophrenia OR depression OR bipolar) AND (antipsychotic OR antidepressant) AND (venous thromboembolism OR pulmonary embolism) AND (prevention OR prophylaxis) in 2006.

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Development and evaluation of PEGylated Enoxaparin: A novel approach for enhanced anti-Xa activity

Choubey

Dora

Bhatt

et al. 2014

Bioorganic Chemistry

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Management of venous thromboembolism

Cited by 3 publications

References 62 publications

Anticoagulation Management Practices and Outcomes in Elderly Patients with Acute Venous Thromboembolism: A Clinical Research Study

Anticoagulation Management Practices and Outcomes in Elderly Patients with Acute Venous Thromboembolism: A Clinical Research Study

Assessment of risk of venous thromboembolism and its possible prevention in psychiatric patients

Development and evaluation of PEGylated Enoxaparin: A novel approach for enhanced anti-Xa activity

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