Management of ventricular tachycardia in patients with cardiac sarcoidosis

Abstract

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Enhanced oxidative stress and presence of ventricular aneurysm for risk prediction in cardiac sarcoidosis

“…All patients underwent 12-lead ECG, echocardiography, and 18 F-FDG-PET/CT or 67 Ga scintigraphy. All patients were monitored by Holter ECG, an ECG monitor (Nihon Kohden, Tokyo) or an implantable device (implantable cardioverterdefibrillator, cardiac resynchronisation therapy defibrillator or dual-chamber pacemaker).…”

“…All patients underwent 18 F-FDG-PET/CT examinations after fasting for 18 hours and the whole body and heart were visualised. Quantitative analysis of 18 F-FDG uptake in lesions was performed using maximum standardised uptake value measurements.…”

“…All patients underwent 18 F-FDG-PET/CT examinations after fasting for 18 hours and the whole body and heart were visualised. Quantitative analysis of 18 F-FDG uptake in lesions was performed using maximum standardised uptake value measurements. 10-12 15 Steroid treatment protocol for patients with active-positive CS Corticosteroid treatment (prednisolone) was initiated according to existing Japanese protocols as follows: 30 mg/day for 4 weeks with gradual tapering of the dose to 5-10 mg every other day over 6 months to establish the minimal effective dose.…”

“…1 Recent studies have shown that patients with CS have an increased risk of sudden cardiac death (SCD), which accounts for most lethal ventricular arrhythmias. [1][2][3] With new modalities, relevant prognostic information from techniques such as 18 F-fluorodeoxyglucose ( 18 F-FDG)-positron emission tomography (PET), cardiac magnetic resonance imaging and programmed electrical stimulation has been reported as useful in predicting fatal arrhythmias in CS. [4][5][6][7][8] 8-hydroxy-2′-deoxyguanosine (8-OHdG), an oxidative stress marker, is produced by oxidation of 2′-deoxyguanosine, a DNA base, under cellular oxidative stress conditions.…”

“…Furthermore, urinary 8-OHdG (U-8-OHdG) levels are significantly correlated with the inflammatory activity observed on 18 F-FDG-PET in CS [9][10][11] as well as the degree of oxidative stress in myocardial biopsy tissue. 12 We previously reported that U-8-OHdG levels had a significant positive correlation with myocardial fibrosis.…”