Diyala River is the third largest tributary of the Tigris River running 445 km length and draining an area of 32,600 km 2 .The river is the major source of water supply for Diyala City for municipal, domestic, agriculture and other purposes. Diyala River Basin currently is suffering from water scarcity and contamination problems. Up-to-date studies have shown that blue and green waters of a basin have been demonstrating increasing variability contributing to more severe droughts and floods seemingly due to climate change. To obtain better understanding of the impacts of climate change on water resources in Diyala River Basin in near 2046~2064 and distant future 2080~2100, SWAT (soil and water assessment tool) was used. The model is first examined for its capability of capturing the basin characteristics, and then, projections from six GCMs (general circulation models) are incorporated to assess the impacts of climate change on water resources under three emission scenarios: A2, A1B and B1. The results showed deteriorating water resources regime into the future.