Management Strategies for Atypical Parkinsonism

Constantinides, Vasilios C.; Giagkou, Nikolaos; Brinia, Maria-Evgenia; Koros, Christos; Stefanis, Leonidas; Stamelou, Maria

doi:10.1007/s11940-024-00787-6

Curr Treat Options Neurol

2024

DOI: 10.1007/s11940-024-00787-6

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Management Strategies for Atypical Parkinsonism

Vasilios C. Constantinides,

Nikolaos Giagkou,

Maria-Evgenia Brinia

et al.

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Cited by 2 publications

References 113 publications

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Quantifying Lenition as a Diagnostic Marker for Parkinson’s Disease and Atypical Parkinsonism

Wayland,

Meyer,

Reddy

et al. 2024

BioMedInformatics

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Objective: This study aimed to evaluate lenition, a phonological process involving consonant weakening, as a diagnostic marker for differentiating Parkinson’s Disease (PD) from Atypical Parkinsonism (APD). Early diagnosis is critical for optimizing treatment outcomes, and lenition patterns in stop consonants may provide valuable insights into the distinct motor speech impairments associated with these conditions. Methods: Using Phonet, a machine learning model trained to detect phonological features, we analyzed the posterior probabilities of continuant and sonorant features from the speech of 142 participants (108 PD, 34 APD). Lenition was quantified based on deviations from expected values, and linear mixed-effects models were applied to compare phonological patterns between the two groups. Results: PD patients exhibited more stable articulatory patterns, particularly in preserving the contrast between voiced and voiceless stops. In contrast, APD patients showed greater lenition, particularly in voiceless stops, coupled with increased articulatory variability, reflecting a more generalized motor deficit. Conclusions: Lenition patterns, especially in voiceless stops, may serve as non-invasive markers for distinguishing PD from APD. These findings suggest potential applications in early diagnosis and tracking disease progression. Future research should expand the analysis to include a broader range of phonological features and contexts to improve diagnostic accuracy.

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Quantifying Lenition as a Diagnostic Marker for Parkinson’s Disease and Atypical Parkinsonism

Wayland,

Meyer,

Reddy

et al. 2024

BioMedInformatics

View full text Add to dashboard Cite

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Acute Levodopa Challenge in Atypical Parkinsonism: Comprehensive Analysis of Individual Motor Responses

Ye,

Sani,

Veith Sanches

et al. 2024

Brain Sciences

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The acute levodopa challenge is widely used to distinguish Parkinson’s disease (PD) from atypical parkinsonian syndromes (APSs) such as multiple system atrophy (MSA) and progressive supranuclear palsy (PSP). In APSs, very few patients present a clinically relevant response to levodopa. The aim of this study was to determine whether patients with atypical parkinsonism benefit from levodopa in any aspect of their multiple motor deficits despite the generally poor response. This retrospective study analyzed individual motor responses to the acute levodopa challenge using the MDS-UPDRS III in 47 PSP, 26 MSA, and 71 PD patients at Hannover Medical School. Despite the generally poor levodopa response in both PSP and MSA patients, bradykinesia and rigidity were the symptoms most notably affected by levodopa in PSP patients, while MSA patients experienced significant improvements in bradykinesia and action tremor. These findings underscore the variability in levodopa response among PSP and MSA patients and highlight the need for personalized treatment approaches in atypical parkinsonism.

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Management Strategies for Atypical Parkinsonism

Cited by 2 publications

References 113 publications

Quantifying Lenition as a Diagnostic Marker for Parkinson’s Disease and Atypical Parkinsonism

Quantifying Lenition as a Diagnostic Marker for Parkinson’s Disease and Atypical Parkinsonism

Acute Levodopa Challenge in Atypical Parkinsonism: Comprehensive Analysis of Individual Motor Responses

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