Managing a malignant orocutaneous fistula: stem the tide with octreotide?

Gibson, Stanley; Strutt, Rebecca; Chye, Richard

doi:10.1046/j.1444-0903.2001.00190.x

Cited by 6 publications

(8 citation statements)

References 3 publications

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“…The treatment of pathological mandibular fractures associated with malignant or benign neoplasms has to be directed toward the disease process that must be considered the first priority . Pathological fractures are more frequently associated with metastatic tumors or primary oral squamous cell carcinoma (Table ).…”

Section: Mandibular Fractures Associated With a Malignant Pathology/bmentioning

confidence: 99%

“…The most frequently involved site is mandibular angle (4,52,53,56,57,62,63,67), followed by body (3,43,46,50,54,55,59,61,66) and condyle (3,(46)(47)(48)(49)60).…”

Section: Mandibular Fractures Associated With Benign Cystic Pathologymentioning

confidence: 99%

“…Pathological fractures usually may be determined by surgical interventions (third molar removal and implant placement), result from regions of osteomyelitis, osteoradionecrosis (ORN), and bisphosphonate‐related osteonecrosis of the jaw (BRONJ), occur because of idiopathic reasons or be facilitated by cystic lesions, benign, malignant, or metastatic tumors .…”

mentioning

confidence: 99%

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Pathological mandibular fractures: a review of the literature of the last two decades

Boffano

Roccia

Gallesio

et al. 2013

Dental Traumatology

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Section: Mandibular Fractures Associated With a Malignant Pathology/bmentioning

confidence: 99%

“…The most frequently involved site is mandibular angle (4,52,53,56,57,62,63,67), followed by body (3,43,46,50,54,55,59,61,66) and condyle (3,(46)(47)(48)(49)60).…”

Section: Mandibular Fractures Associated With Benign Cystic Pathologymentioning

confidence: 99%

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Pathological mandibular fractures: a review of the literature of the last two decades

Boffano

Roccia

Gallesio

et al. 2013

Dental Traumatology

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“…anecdotal and case reports supporting the use of octreotide in the setting of PCF 12,13 that have justified a placebo controlled clinical investigation of octreotide in PCF closure in Israel 14 . We hypothesized that octreotide induces alterations in the saliva proteome, and these alterations may provide insight into the mechanism of action underlying improved PCF healing.…”

Section: 10mentioning

confidence: 99%

Octreotide may improve pharyngocutaneous fistula healing through downregulation of cystatins: a pilot study

Cohen

Reed

Foster

et al. 2022

Preprint

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ObjectivePharyngocutaneous fistula (PCF) and salivary leaks are well known complications of head and neck surgery. The medical management of PCF has included the use of octreotide without a well-defined understanding of its therapeutic mechanism. We hypothesized that octreotide induces alterations in the saliva proteome and that these alterations may provide insight into the mechanism of action underlying improved PCF healing. We undertook an exploratory pilot study in healthy controls that involved collecting saliva before and after a subcutaneous injection of octreotide and performing proteomic analysis to determine the effects of octreotide.Materials and MethodsFour healthy adult participants provided saliva samples before and after subcutaneous injection of octreotide. A mass-spectrometry based workflow optimized for the quantitative proteomic analysis of biofluids was then employed to analyze changes in salivary protein abundance after octreotide administration.ResultsThere were 3,076 human, 332 S. mitis, 102 G. haemolyans and 42 G. adiacens protein groups quantified in saliva samples. A paired statistical analysis was performed using the generalized linear model (glm) function in edgeR. There were and ∼300 proteins that had a p<0.05 between the pre-and post-octreotide groups ∼50 proteins with an FDR-corrected p<0.05 between pre-and post-groups. These results were visualized using a volcano plot after filtering on proteins quantified by 2 more or unique precursors. Both human and bacterial proteins were among the proteins altered by octreotide treatment. Notably, four isoforms of the human cystatins, belonging to a family of cysteine proteases, that had significantly lower abundance after treatment.ConclusionThis pilot study demonstrated octreotide-induced downregulation of cystatins. By downregulation of cystatins in the saliva, there is decreased inhibition of cysteine proteases such as Cathepsin S. This results in increased cysteine protease activity that has been linked to enhanced angiogenic response, cell proliferation and migration that have resulted in improved wound healing. These insights provide first steps at furthering our understanding of octreotide’s effects on saliva and reports of improved PCF healing.

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“…Enterocutaneous fistulae associated with malignancies cause dehydration, electrolyte disturbance, and skin breakdown [46]. Case reports describe the benefits of octreotide for the treatment of fistulae associated with melanoma [47] or sarcoma [48]. Most benefits derive from decreased drainage and less frequent dressing changes.…”

Section: Palliation Of Malignant Fistulaementioning

confidence: 99%

Established and potential therapeutic applications of octreotide in palliative care

Prommer

2008

Support Care Cancer

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Octreotide acetate was developed as a pharmacologically stable, long-acting analogue of the hormone somatostatin. Mimicking the actions of somatostatin, octreotide has been used for its antisecretory effects. Randomized control trials have established the efficacy of octreotide for malignant bowel obstruction and for chemotherapy-induced diarrhea. Octreotide has proven to be an effective agent for symptoms of carcinoid syndrome. Newer uses include for bone marrow transplantation, infectious diarrheal syndromes, and management of hepatic metastases. More evidence is needed for the establishment of its efficacy for hypercalcemia, pain, pleural effusions, diarrhea after celiac plexus block, and malignant ascites.

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Managing a malignant orocutaneous fistula: stem the tide with octreotide?

Cited by 6 publications

References 3 publications

Pathological mandibular fractures: a review of the literature of the last two decades

Pathological mandibular fractures: a review of the literature of the last two decades

Octreotide may improve pharyngocutaneous fistula healing through downregulation of cystatins: a pilot study

Established and potential therapeutic applications of octreotide in palliative care

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