This chapter underscores the critical importance of embracing alternative fuels, specifically natural gas and hydrogen, as pivotal elements in the concerted effort to decarbonise road freight operations. It accentuates the necessity for collaborative, well-informed decision-making processes to navigate the complexities of this transition successfully. The exploration extends beyond technological considerations to encompass policy-driven initiatives adopted by nations like Norway, India, the USA, the UK, South Africa, and Germany, among others. Notably, it scrutinises instances of demonstrated economic viability associated with specific decarbonisation strategies employed in these regions. Moreover, the chapter advocates for sustained interdisciplinary research efforts to comprehensively address the diverse challenges posed by regional variations, industry-specific requirements, operational environments, cross-cultural influences, and the integration of sustainability metrics. By emphasising the importance of ongoing technological innovation, robust policy frameworks, and thoughtful economic considerations, the chapter envisions a global roadmap for sustainable road freight practices. In essence, it calls for a holistic approach, urging scholars, policymakers, and industry experts to collaboratively shape a sustainable future for road freight that addresses the intricate interplay of technological advancements, policy dynamics, and economic imperatives on a global scale.