Managing Brown Adipose Tissue (BAT) Uptake in 18F FDG PET Oncology Studies

Skillen, Annah; Currie, Geoffrey

doi:10.1016/j.jmir.2014.03.067

Cited by 2 publications

(1 citation statement)

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“…Perhaps most apparent is that FDG uptake in BAT can be suppressed by a number of different strategies, which are often employed to prevent obscuration or misinterpretation on oncology staging and restaging examinations. These methods include core warming, controlling the environmental temperature, [174][175][176][177][178][179][180][181] or pharmacologic approaches. 180,[182][183][184][185][186][187][188][189][190] That all of these methods exist to modulate BAT uptake on FDG-PET suggests that it is not an ideal gold standard and that other radiotracers might be preferable.…”

Section: Qualitative Analysis Of Bat Studies Classified According To Imaging Modalitiesmentioning

confidence: 99%

A systematic review of imaging studies of human brown adipose tissue

Santhanam

Rowe

Solnes

et al. 2021

Annals of the New York Academy of Sciences

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Brown adipose tissue (BAT) is involved in energy dissipation and has been linked to weight loss, insulin sensitivity, and reduced risk of atherosclerotic disease. BAT is found most often in the supraclavicular region, as well as mediastinal and paravertebral areas, and it is predominantly seen in young persons. BAT is activated by cold temperature and the sympathetic nervous system. In humans, BAT was initially detected via 2-deoxy-2-[ 18 F]fluorod-glucose (FDG) positron emission tomography/computed tomography (PET/CT), a high-resolution molecular imaging modality used to identify and stage malignancies. Recent studies have shown that BAT can be localized using conventional imaging modalities, such as CT or magnetic resonance imaging, as well as radiotracers used for single-photon emission CT. In this systematic review, we have summarized the evidence for BAT detection in humans using various imaging techniques.

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