Managing Chronic Pain: Are Gabapentinoids Being Misused?

Anantharamu, Tejus; Govind, Mathur A

doi:10.2217/pmt-2018-0018

Cited by 3 publications

(3 citation statements)

References 16 publications

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“…Interestingly, the ICD-10 diagnosis of substance dependence of our study subjects was set approximately three years before their first gabapentinoid prescriptions. Thus, our study findings, from a clinical sample of former adolescent psychiatric inpatients, highlights the potential for misuse of gabapentinoids and, above all, emphasizes the importance of carefully considering prescribing gabapentinoids to individuals at high-risk of drug abuse (Chiappini & Schifano, 2016;Bonnet & Scherbaum, 2017), including patients with chronic pain (Anantharamu & Govind, 2018).…”

Section: Discussionmentioning

confidence: 64%

Profile of Substance Misuse among Adolescent and Young Adult Gabapentinoid Users: A Register-Based Follow-up Study of Former Adolescent Psychiatric Inpatients

Peltokorpi

Hakko

Riipinen

et al. 2021

Substance Use & Misuse

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Aims: Our study examined characteristics of adolescent and young adult study participants using gabapentinoids (gabapentin, pregabalin), with previous history of adolescent psychiatric inpatient hospitalization. Particular focus was on temporal association of age, at first prescription for gabapentinoids, to age at tobacco smoking initiation, regular alcohol use, diagnosis of substance dependence and prescriptions for benzodiazepines and opioids. Methods: The initial study population contained 508 adolescents (300 females, 208 males) admitted to psychiatric inpatient care in Oulu University hospital between the ages 13-17 years. Register-based follow-up information on prescriptions for gabapentinoids, benzodiazepines and opioids, as well as ICD-10 diagnosis for hospital-treated substance dependence, was obtained from the Finnish national health care registers. Results: The users of gabapentinoids accounted for 9.1% of the initial study population. Of adolescence-related characteristics, suicidal ideation, suicide attempts and non-suicidal self-injury was emphasized in females using gabapentinoids. The majority of participants using gabapentinoids had benzodiazepines (80.4%) and opioids (71.7%) as comorbid drugs. Initiation of tobacco smoking and alcohol use and first prescriptions for of benzodiazepines and opioids, and a diagnosis of substance dependence commonly predated first prescriptions for gabapentinoids. Conclusions: In clinical practice, the decision to prescribe gabapentinoids to adolescents or young adults must be made with caution, particularly for those with substance use problems and/or without a clinically approved indication.

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Section: Discussionmentioning

confidence: 64%

Profile of Substance Misuse among Adolescent and Young Adult Gabapentinoid Users: A Register-Based Follow-up Study of Former Adolescent Psychiatric Inpatients

Peltokorpi

Hakko

Riipinen

et al. 2021

Substance Use & Misuse

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“…Baftiu et al report that antiepileptic drugs such as gabapentinoids are now being used for indications other than epilepsy [ 11 ]. Furthermore, an estimate by Anantharamu et al suggests that over 95% of gabapentinoid prescriptions are used outside the three approved indications [ 10 ]. In the USA, prescriptions for these molecules have more than tripled in the last 10 years, as described by Johansen et al and Montastruc et al [ 12 , 13 ].…”

Section: Discussionmentioning

confidence: 99%

“…As for PGB, it was approved for neuropathic pain (including post-herpetic neuralgia), fibromyalgia and convulsions [ 9 ]. However, gabapentinoids prescriptions have significantly increased in recent years in the management of non-FDA-approved musculoskeletal conditions [ 10 , 11 ].…”

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confidence: 99%

Gabapentinoid prescriptions for neuropathic and musculoskeletal pain in Lebanon

Rassi,

Khazaka,

Hlais

et al. 2024

Future Science OA

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Aim: The purpose of this study is to analyze the different characteristics of gabapentinoids prescription by Lebanese orthopedics surgeons. Methods: This is an observational, cross-sectional study using a survey which was carried out in collaboration with the Lebanese Orthopedic Society over a 3-month period. Results: Forty-two orthopedic surgeons responded, most of them prescribing gabapentinoids in their daily practice with only half of the patients feeling relief after taking them. Furthermore, most of the surgeons prescribed these drugs for patients above 18 years old and for both acute and chronic pain. Conclusion: Even though almost half of the patients do not experience relief after taking gabapentinoids, these drugs are becoming more and more prescribed.

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Journey of Oliceridine

Sinha¹,

Tejus²,

Mohan³

et al. 2022

Journal of Marine Medical Society

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Opioid analgesics play a crucial role in the management of acute pain, but its use is often limited by various adverse effects, especially nausea, vomiting, and respiratory depression. There has always been an attempt to develop analgesics that are equi-efficacious to opioids but carry less risk of respiratory depression. Oliceridine has been the first among such biased/selective molecules approved by the United States Food and Drug Administration. Oliceridine is proposed to act selectively on mu-opioid receptors producing analgesia but does not propagate β-arrestin mediated mechanism postulated to be responsible for respiratory depression of other opioids, especially morphine. Oliceridine has favorable pharmacokinetics for intravenous administration and no significant drug interactions have been proposed.

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Managing Chronic Pain: Are Gabapentinoids Being Misused?

Cited by 3 publications

References 16 publications

Profile of Substance Misuse among Adolescent and Young Adult Gabapentinoid Users: A Register-Based Follow-up Study of Former Adolescent Psychiatric Inpatients

Profile of Substance Misuse among Adolescent and Young Adult Gabapentinoid Users: A Register-Based Follow-up Study of Former Adolescent Psychiatric Inpatients

Gabapentinoid prescriptions for neuropathic and musculoskeletal pain in Lebanon

Journey of Oliceridine

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