Managing constipation in children with ASD – A challenge worth tackling

Mulay, Kalyani Vijaykumar; Karthik, S.

doi:10.1016/j.pedneo.2021.11.009

Cited by 3 publications

(2 citation statements)

References 61 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In a previous review, the median prevalence of constipation was reported to be 22% ( 51 ). Most ASD patients have functional constipation associated with mitochondrial dysfunction, gut flora composition, and unusual dietary patterns ( 52 ). A 2012 study found that a gluten-free, casein-free (GFCF) diet may be useful in improving behavioral outcomes in children with constipation compared to children with ASD without bowel-related symptoms ( 53 ).…”

Section: Discussionmentioning

confidence: 99%

Global prevalence of autism spectrum disorder and its gastrointestinal symptoms: A systematic review and meta-analysis

Wang

et al. 2022

Front. Psychiatry

View full text Add to dashboard Cite

BackgroundAutism spectrum disorder (ASD) is a severe public health concern, and Gastrointestinal (GI) symptoms are becoming more common among co-morbidities. The evidence has to be updated depending on differences in different parts of the world. This systematic review and meta-analysis aimed to better understand the existing epidemiological condition and help make health-related decisions.MethodsSearches in PubMed, Web of Science, Embase databases are limited to 14 March 2022. We reviewed the global prevalence of ASD and the prevalence of GI in people with ASD. Data were extracted by two independent researchers. Literature quality assessment using the National Institutes of Health Study Quality Assessment Tool.ResultsWe discovered that the global pooled prevalence of ASD was 98/10,000 (95% confidence interval, 95%CI: 81/10,000–118/10,000, I2 = 99.99%, p < 0.001), with 48.67% (95%CI: 43.50 −53.86, I2 = 99.51%) of individuals with ASD reporting GI symptoms. Based on the subgroup analyses, we found a higher prevalence of ASD in males (90/10,000, 95%CI: 71/10,000–112/10,000, I2 = 99.99%) than females (21/10,000, 95%CI: 15/10,000–27/10,000, I2 = 99.99%). Prevalence of pooling is higher in developing countries (155/10,000, 95% CI: 111/10,000–204/10,000, I2 = 99.87%) than in developed countries (85/10,000, 95%CI: 67/10,000-105/10,000, I2 = 99.99%).ConclusionThe global prevalence of ASD and the prevalence of GI symptoms in ASD are both significant. The prevalence of ASD is much higher in men than in women. Further attention to ASD and its related comorbidities will be required in the future to inform coping strategy adaptation.

show abstract

Section: Discussionmentioning

confidence: 99%

Global prevalence of autism spectrum disorder and its gastrointestinal symptoms: A systematic review and meta-analysis

Wang

et al. 2022

Front. Psychiatry

View full text Add to dashboard Cite

show abstract

“…Individuals with sensory sensitivities may need gradual food diversification and the introduction of new textures and tastes[ 97 ]. Staying hydrated by drinking plenty of fluids, especially water, can help soften the stool and ease bowel movements[ 98 ]. Establishing a regular bathroom routine, preferably after meals, can also help develop a consistent routine for bowel movements.…”

Section: Introductionmentioning

confidence: 99%

Role of gastrointestinal health in managing children with autism spectrum disorder

Al-Beltagi,

Saeed,

Bediwy

et al. 2023

World J Clin Pediatr

View full text Add to dashboard Cite

Investigating gastrointestinal (GI) motility disorders relies on diagnostic tools to assess muscular contractions, peristalsis propagation and the integrity and coordination of various sphincters. Manometries are the gold standard to study the GI motor function but it is increasingly acknowledged that manometries do not provide a complete picture in relation to sphincters competencies and muscle fibrosis. Endolumenal functional lumen imaging probe (EndoFLIP) an emerging technology, uses impedance planimetry to measure hollow organs cross sectional area, distensibility and compliance. It has been successfully used as a complementary tool in the assessment of the upper and lower oesophageal sphincters, oesophageal body, the pylorus and the anal canal. In this article, we aim to review the uses of EndoFLIP as a tool to investigate GI motility disorders with a special focus on paediatric practice. The majority of EndoFLIP studies were conducted in adult patients but the uptake of the technology in paediatrics is increasing. EndoFLIP can provide a useful complementary data to the existing GI motility investigation in both children and adults.

show abstract

Associations of Autistic Traits and Autism with Incontinence and Constipation in a UK Birth Cohort

Gyamenah,

Burrows,

Rai

et al. 2024

J Autism Dev Disord

View full text Add to dashboard Cite

There is evidence that children with autism/autistic traits have higher risks of incontinence and constipation, but no studies have examined this in a large community-based cohort. Aim/Research question: are autistic traits and diagnosed autism prospectively associated with increased odds of incontinence and constipation in children and adolescents? This was a population-based cohort study based on data from the Avon Longitudinal Study of Parents and Children (n = 4233–4490 at age 9 years; n = 3403–3697 at age 14). We used multivariable logistic regression to examine associations of parent-reported autistic traits (sociability, repetitive behaviours, social-communication, coherence) (at ages 3–9 years) and autism with incontinence (bedwetting, daytime-wetting, soiling) and constipation (parent-reported at age 9, self-reported at age 14). We adjusted for parity, maternal age at delivery, child’s sex and developmental level, maternal depression, and anxiety (antenatal and postnatal), and indicators of family socioeconomic status. Social-communication and speech coherence difficulties showed the strongest associations with incontinence, e.g., adjusted odds ratio (OR) and 95% confidence interval (CI) for the association between social-communication difficulties and daytime-wetting was 2.21 (1.47–3.32) and for coherence was 2.34 (1.60–3.43). The odds of soiling were also higher in children with social-communication (OR: 1.88, 95% CI 1.28–2.75) and coherence difficulties (OR: 2.04, 95% CI 1.43–2.93). Diagnosed autism was only associated with an increase in the odds of daytime-wetting (OR: 3.18, 95% CI 1.44–7.02). At 14 years, there was less evidence of associations between autistic traits and incontinence but there was evidence of associations between autistic traits and constipation: social-communication (OR: 1.68, 95% CI 1.13–2.49), coherence difficulties (OR: 1.64, 95% CI 1.11–2.41). Early assessment and treatment of incontinence/constipation should be considered for children with autistic traits.

show abstract

Managing constipation in children with ASD – A challenge worth tackling

Cited by 3 publications

References 61 publications

Global prevalence of autism spectrum disorder and its gastrointestinal symptoms: A systematic review and meta-analysis

Global prevalence of autism spectrum disorder and its gastrointestinal symptoms: A systematic review and meta-analysis

Role of gastrointestinal health in managing children with autism spectrum disorder

Associations of Autistic Traits and Autism with Incontinence and Constipation in a UK Birth Cohort

Contact Info

Product

Resources

About