Managing excessive saliva with salivary gland irradiation in patients with amyotrophic lateral sclerosis

Slade, Alexander N.; Stanic, Sinisa

doi:10.1016/j.jns.2015.02.008

Cited by 9 publications

(1 citation statement)

References 16 publications

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“…Whilst there are studies suggesting that salivary gland irradiation may be an effective treatment, its use was not reported in this study [27]. Additionally, no surgical options were used which may reflect the invasive nature of these interventions and the frailty of this patient group.…”

Section: Discussionmentioning

confidence: 92%

A multicentre evaluation of oropharyngeal secretion management practices in amyotrophic lateral sclerosis

McGeachan

Hobson

Al‐Chalabi

et al. 2016

Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration

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Objective: Failure to clear oral secretions can be debilitating for patients with amyotrophic lateral sclerosis, ALS, but the treatment of this symptom is poorly defined and there is no consensus on best practice. The objective of this study was to identify the treatments that are commonly prescribed, and to describe how experienced clinicians manage a patient with treatment resistant symptoms.Methods: Twenty-three clinicians were approached, of which 19 from 16 centres across the UK provided case report forms for a total of 119 ALS patients identified as having problematic oral secretions.Results: The use of five anticholinergics, salivary gland botulinum toxin injections, conservative management approaches and carbocisteine were reported. Of the 72 patients who were evaluated following the initiation of a first anticholinergic, 61% had symptomatic improvement. Only 19% of patients achieved symptomatic improvement with the use of an alternative anticholinergic when an initial anticholinergic achieved no symptomatic improvement. Problems with thick and thin secretions often co-existed with 37% of patients receiving treatment for both types of problem.Conclusion: A variety of treatment options are employed by expert clinicians for problematic oral secretions in ALS patients. The variation in management highlights the need for further prospective research in this area.

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Section: Discussionmentioning

confidence: 92%