COMMENT & RESPONSEIn Reply We thank Hashemi et al for their engagement and thoughtful reply to our article 1 that highlighted their experience with tranexamic acid (TA) and procedural therapies. We agree that treatment approaches in hyperpigmentation have had great advancements. We also recognize that tranexamic acid offers an additional option for treating melasma, as we discussed in our article. 1 However, more guidance is needed on optimal therapeutic ranges, dosing regimens, length of treatment, and effects on certain patient populations, such as those receiving hormonal treatments and/or with hypercoagulable disorders. While TA has a prominent role in the treatment paradigm of melasma, it is not without risks and should be used and offered with proper medical judgment.We also agree that lasers offer an additional therapeutic option, especially as more novel lasers have proven safe and effective on pigmented skin. Low-density fractional nonablative resurfacing lasers, picosecond, Q-switched, and diode lasers, along and with other advanced laser technology, have supporting evidence for their use in disorders of hyperpigmentation; however, access and costs limit their use as firstline agents. The first barrier may be a consultation fee, followed by a series of treatments 2,3 that can be upwards of $1000 each. Furthermore, many individuals do not have access to board-certified dermatologists who can offer safe and effective laser treatments for their pigmentary disorders, and not all clinicians have the comfort or training to offer such services across all skin tones, especially for people with darker skin tones who are at higher risk for scarring and dyspigmentation after procedural interventions. As carefully noted by Hashemi et al, not all lasers are equivalent, and using lasers at inappropriate settings, such as higher energies and densities, can worsen PIH and melasma, with increased risk in darker skin tones.We agree and appreciate the interest of Hashemi et al and the expansion of our article. Lasers and oral options have broadened our ability to treat difficult disorders of hyperpigmentation. First-line treatments remain photoprotection and topicalbased modalities given the balance of risks and benefits, efficacy, less cost, and more access compared with therapeutic outcomes of procedural interventions.