Managing joint pain in osteoarthritis: safety and efficacy of hylan G-F 20

Conduah, Augustine; Baker, Champ L.

doi:10.2147/jpr.s4732

Cited by 13 publications

(3 citation statements)

References 84 publications

(108 reference statements)

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“…As the main component of intra-articular synovial fluid, HA is present in the upper layer of articular cartilage 1-2 microns. 28 Compared with normal knees containing 2.5 to 4 mg/mL of HA, the knee of patients with osteoarthritis has a decrease of 1 to 2 mg/mL due to reduced production of HA and increased self-degradation and clearance, with a reduction of up to 50%. 27 Since it was approved by Food and Durg Administration (FDA) for the treatment of OA in the United States in 1997, hyaluronic acid has been widely used.…”

Section: Hyaluronic Acid (Ha)mentioning

confidence: 99%

<p>Development and Prospect of Intra-Articular Injection in the Treatment of Osteoarthritis: A Review</p>

Yin

Chen

Yu³

et al. 2020

JPR

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Osteoarthritis (OA) is a common degenerative disease that affects the vast majority of the elderly and may eventually embark on the road of the total knee arthroplasty (TKA), although controversy still exists in the medical community about the best therapies for osteoarthritis. Compared with physical therapy, oral analgesics and other non-operative treatments, intra-articular injection is more safe and effective. Moreover, intra-articular injection is much less invasive and has fewer adverse reactions than surgical treatment. This article reviews mechanism, benefits and adverse reactions of corticosteroids (CS), hyaluronic acid (HA), platelet-rich plasma (PRP), mesenchymal stem cell (MSCs), stromal vascular fraction (SVF) and other new therapies (for example: gene therapy). The application prospect of intra-articular injection was analyzed according to the recent progress in drug research.

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Section: Hyaluronic Acid (Ha)mentioning

confidence: 99%

<p>Development and Prospect of Intra-Articular Injection in the Treatment of Osteoarthritis: A Review</p>

Yin

Chen

Yu³

et al. 2020

JPR

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“…Since during the knee OA the degradation of synovial fluid hyaluronate occurs, therefore it has been assumed that the intra-articular injection of HA could ameliorate the functional impairment and knee joint pain. In this regard, HA has been considered as a pharmacologic option and was approved by the FDA for knee OA in 1997 and recommended as an effective treatment for knee OA in the guideline of the American College of Rheumatology in 2000 [ 16 , 17 ]. However, due to the controversial results, there is no agreement regarding the management of knee OA with intra-articular HA injections.…”

Section: Introductionmentioning

confidence: 99%

The comparison effects of intra-articular injection of Platelet Rich Plasma (PRP), Plasma Rich in Growth Factor (PRGF), Hyaluronic Acid (HA), and ozone in knee osteoarthritis; a one year randomized clinical trial

Raeissadat

Hosseini

Bahrami

et al. 2021

BMC Musculoskelet Disord

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Background Our study compare the short and long-term efficacy of the intra articular injections (IAIs) of hyaluronic acid (HA), platelet-rich plasma (PRP), plasma rich in growth factors (PRGF), and ozone in patients with knee osteoarthritis (OA). Methods In this randomized clinical trial, 238 patients with mild to moderate knee OA were randomized into 4 groups of IAIs: HA (3 doses weekly), PRP (2 doses with 3 weeks interval), PRGF (2 doses with 3 weeks interval), and Ozone (3 doses weekly). Our outcome measures were the mean changes from baseline (immediately from the first injections) until 2,6, and 12 months post intervention in scores of visual analog scale (VAS), Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), and Lequesne index. Results A total of 200 patients enrolled in the final analysis. The mean age of patients was 56.9 ± 6.3 years, and 69.5% were women. In 2 months follow up, significant improvement of pain, stiffness, and function were seen in all groups compared to the baseline, but the ozone group had the best results (P < 0.05). In 6 month follow up HA, PRP, and PRGF groups demonstrated better therapeutic effects in all scores in comparison with ozone (P < 0.05). At the end of the 12th month, only PRGF and PRP groups had better results versus HA and ozone groups in all scores (P < 0.05). Despite the fact that ozone showed better early results, its effects begin to wear off earlier than other products and ultimately disappear in 12 months. Conclusions Ozone injection had rapid effects and better short-term results after 2 months, but its therapeutic effects did not persist after 6 months and at the 6-month follow up, PRP,PRGF and HA were superior to ozone. Only patients in PRP and PRGF groups improved symptoms persisted for 12 months. Therefore, these products could be the preferable choices for long-term management. Trial registration Registered in the Iranian Center of Clinical Trials (www.irct.ir) in 11/11/2017 with the following code: IRCT2017082013442N17.

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“…31 As part of the physiologic synovial fluid, HA performs not only mechanical functions by maintaining the viscoelasticity of the synovial fluid, but also chondroprotective and anti-inflammatory functions. [31][32][33][34] As the concentration of native HA is reduced to approximately 50% of its physiologic concentration in OA, 35 an intraarticular injection of HA exhibits instant dual mechanical effects. As such, it functions as a lubricant during slow, low shear rate movements by increasing synovial viscosity and also provides shock absorption during rapid, high shear rate movements in its structure as an elastic solid.…”

Section: Discussionmentioning

confidence: 99%

Efficacy of intra‐articular injections of hyaluronic acid in patients with glenohumeral joint osteoarthritis: A systematic review and meta‐analysis

Familiari

Ammendolia

Rupp

et al. 2023

Journal Orthopaedic Research

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Symptomatic primary glenohumeral (GH) joint osteoarthritis (OA) can be challenging to treat. Hyaluronic acid (HA) has emerged as a promising treatment for the nonsurgical management of GH‐OA. In this systematic review with meta‐analysis, we aimed to evaluate the current evidence regarding the efficacy of intra‐articular HA on pain relief in patients suffering from GH‐OA. A total of 15 studies (only randomized controlled trials providing data at the end of the intervention) were included. The relevant studies were selected based on the following PICO model: P: patients with diagnosis of shoulder OA; I: HA infiltrations as therapeutic intervention administered; C: no restriction for comparators assessed; O: pain, in terms of visual analog scale (VAS) or numeric rating scale. The risk of bias among the included studies was estimated using the PEDro scale. A total of 1023 subjects were analyzed. Comparing HA injections combined with physical therapy (PT) compared to PT alone resulted in superior scores, showing an overall effect size (ES) of 4.43 (p = 0.00006). Moreover, pooled analysis of VAS pain scores demonstrated a significant improvement in the ES of the HA in comparison with corticosteroid injections (p = 0.002). On average, we reported a PEDro score of 7.2. A total of 46.7% of studies showed probable signs of a randomization bias. The findings of this systematic review and meta‐analysis showed that IA injections of HA might be effective on pain relief with significant improvements compared to baseline and compared to corticosteroid injections in patients affected by GH‐OA.

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Managing joint pain in osteoarthritis: safety and efficacy of hylan G-F 20

Cited by 13 publications

References 84 publications

<p>Development and Prospect of Intra-Articular Injection in the Treatment of Osteoarthritis: A Review</p>

<p>Development and Prospect of Intra-Articular Injection in the Treatment of Osteoarthritis: A Review</p>

The comparison effects of intra-articular injection of Platelet Rich Plasma (PRP), Plasma Rich in Growth Factor (PRGF), Hyaluronic Acid (HA), and ozone in knee osteoarthritis; a one year randomized clinical trial

Efficacy of intra‐articular injections of hyaluronic acid in patients with glenohumeral joint osteoarthritis: A systematic review and meta‐analysis

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