2020
DOI: 10.4097/kja.20436
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Managing rebound pain after regional anesthesia

Abstract: Rebound pain after regional anesthesia can be defined as transient acute postoperative pain that ensues following resolution of sensory blockade, and is clinically significant, either with regard to the intensity of pain or the impact on psychological well-being, quality of recovery, and activities of daily living. Current evidence suggests that it represents an unmasking of the expected nociceptive response in the absence of adequate systemic analgesia, rather than an exaggerated hyperalgesic phenomenon induc… Show more

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Cited by 62 publications
(90 citation statements)
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References 86 publications
(162 reference statements)
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“…14 Alternatively, it may represent a form of exaggerated hyperalgesia uniquely associated with local anaesthetic use. 7 Current evidence supports the former concept. 7 Regardless of the mechanism, it is a fact that many patients who receive regional anaesthesia, either as the sole anaesthetic technique or combined with general anaesthesia or sedation, experience intense pain upon resolution of sensory block.…”
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confidence: 73%
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“…14 Alternatively, it may represent a form of exaggerated hyperalgesia uniquely associated with local anaesthetic use. 7 Current evidence supports the former concept. 7 Regardless of the mechanism, it is a fact that many patients who receive regional anaesthesia, either as the sole anaesthetic technique or combined with general anaesthesia or sedation, experience intense pain upon resolution of sensory block.…”
mentioning
confidence: 73%
“…2,5 Regional anaesthesia offers many advantages in the ambulatory setting: high-quality perioperative analgesia, reduced opioid requirements, reduced postoperative nausea and vomiting, shorter duration of hospital stay, lower hospital readmission rates, lower rates of nosocomial infection, lower morbidity and mortality, and high levels of patient satisfaction. 3,4,6,7 There is evidence that regional anaesthesia may have a role in reducing the risk of progression from acute to chronic pain. 7,8 It is also believed that regional anaesthesia has immunomodulating effects that may reduce recurrence of some cancers, 7,9 although this remains a controversial issue.…”
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confidence: 99%
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