Manassantin B attenuates obesity by inhibiting adipogenesis and lipogenesis in an AMPK dependent manner

Abstract

Obesity is a chronic metabolic disease with an increasing worldwide prevalence and a major cause for development of many metabolic, cardiovascular, and chronic inflammatory diseases, such as type 2 diabetes mellitus (T2DM), dyslipidaemia, nonalcoholic fatty liver disease (NAFLD), hypertension, coronary heart disease, and stroke. 1 The increased mass

Anti-obesity effects of a standardized ethanol extract of Eisenia bicyclis by regulating the AMPK signaling pathway in 3T3-L1 cells and HFD-induced mice

“…52 The activation of AMPK, as an important upstream modulator, inhibits adipogenesis and lipogenesis by downregulating PPARγ, C/ EBPα, and SREBP. 53,54 In this study, we determined that EEB exerted anti-obesity effects in vitro and in vivo by inhibiting adipogenesis and lipogenesis through the activation of AMPK. Initiation of the transcriptional cascade for adipocyte differentiation is dependent on cell division and cell proliferation during MCE.…”

Targeting Breast Cancer and Their Stem Cell Population through AMPK Activation: Novel Insights

“…AMPK is the master regulator of energy molecules in the body and is involved in glucose and fat metabolism. Phosphorylation of AMPK is a crucial step involved in the inhibition of adipogenesis and lipogenesis [73][74][75]. Fatty acids play crucial roles in maintaining cellular functions and structure.…”