These proceedings describe research, educational and policing program implementation and policy and management strategies related to all aspects of road safety and especially related to the conference theme of Towards Zero: A Fresh Approach. The 2021 conference covers a comprehensive range of topics including speed, infrastructure and road design, education, licensing, vehicle design, impairment due to alcohol, drugs and mobile phones. The conference also presents innovative symposium sessions including interdisciplinary approaches combining safety, the law and design and showcasing successful programs involving at-risk youth, older drivers and safety approaches for non-occupants, specifically when we walk and ride a bicycle. Around 600 delegates from 28 countries attended the on-line virtual conference, held in this format because of COVID 19 restrictions. Authors of accepted Extended Abstracts and Full Papers represented international and local institutions from all aspects of their respective communities including research centres, private companies, government agencies and community groups. The Extended Abstracts and links to Full Papers presented in these Proceedings provide an indication of the important work being done in Australia, New Zealand and internationally as part of the United Nations, One UN Vision for Road Safety to reduce the number of crashes roads by 50 percent by 2030.