“…11 The increase in the availability of CT planning has resulted in advances in the management of mandibular defects in humans, including creation of 3-D models of the affected mandible for surgical planning (such as prebending and improved fitting of titanium plates, optimization of bone-to-bone contact, and shorter duration of surgery), 9,[12][13][14][15][16][17][18][19] creation of prefabricated intraoperative guides (for optimization of the length and number of fibular grafts, improved fitting of titanium plates, and improved postoperative cosmetic appearance and function), 9,16,[19][20][21] and development of CAD-CAM customized and patientspecific 3-D-printed reconstruction plates 9,22 and prostheses. 23 Customized 3-D printing of mandibular prostheses provides several theoretical advantages over other techniques, such as the ability to design the prosthesis to match the geometry and weight of the original mandible to better withstand the bending, torsion, and shear forces associated with mastication as well as the incorporation of tissue engineering technology into the prosthesis to promote its osseous integration. 23 However, despite isolated Web-based reports of the use of customized 3-D-printed prostheses for the reconstruction of mandibular defects in humans, there are no peer-reviewed publications describing the use of a CAD-CAM customized 3-Dprinted prosthesis for mandibular reconstruction in any other species.…”