Mandibular advancement and morphological changes in the mandibles of female mice of different ages

Tagliaro, Maria Luisa; Guimarães, Maria Leticia Rassi; Padilha, Dalva Maria Pereira; Callegari-Jacques, Sídia M.; Jeckel-Neto, Emilio A.

doi:10.1016/j.exger.2006.08.001

Cited by 6 publications

(13 citation statements)

References 27 publications

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“…This study evaluated the morphological changes of the mandible and mandibular condyle associated with aging and the effect of MA, a biomechanical stimulus, in male mice. In agreement with our previous findings in mice (Tagliaro et al,2006), a cephalometric longitudinal study of humans was performed, and researchers observed natural and continuous craniofacial bone growth over a period of 66 years and detected different patterns of growth for men and women (Behrents,1993). These results suggest the potential for growth after mechanical stimulus.…”

Section: Discussionsupporting

confidence: 88%

“…As a result, blood‐vessels proliferate; mesenchymal cells migrate, chondrogenesis is induced, cartilaginous matrix and type II collagen synthesis are enhanced, which together promote the formation of new cartilage and bone (Rabie et al,2003a,b,2004). By contrast, a morphological study in 7‐month‐old female mice showed no condylar growth after 30 days of MA, although the regeneration of cartilage was observed by SEM (Tagliaro et al,2006). In 2‐month‐old male mice, MA produced lower, but not significantly different values, in distance D–GH and in angle BF‐GH (Table 1).…”

Section: Discussionmentioning

confidence: 95%

“…However, mechanical stimuli in the mandible lead to muscle responses, neural activation, the enhancement of growth factors (Petrovic and Stutzmann,1999), and vascular flow (Rabie et al,2002). Condylar cartilage and mandibular bone growth (Petrovic and Stutzmann,1999; Rabie et al,2002), and repair (Tagliaro et al,2006) are the results of this stimulation. Furthermore, the growth response is regulated by the orchestrated influences of many growth and regulatory factors expressed by cellular components in the mandibular condyle (Rabie and Hagg,2002).…”

mentioning

confidence: 99%

“…The stimulus of mandibular advancement (MA) provokes a contraction of the lateral pterygoid muscle, which changes the functional and biomechanical environment of the TMJ (Takahashi et al,1995). In 16‐month‐old female mice, application of the MA stimulus for 30 days results in the enhancement of the length of the mandible, condylar process, and the mandibular condyle as compared to both a control group of females of the same age and to 2‐ and 7‐month‐old MA‐stimulated female mice (Tagliaro et al,2006).…”

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confidence: 99%

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Morphological Changes in the Mandible of Male Mice Associated With Aging and Biomechanical Stimulus

Tagliaro

Oliveira

Padilha

et al. 2009

The Anatomical Record

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Degenerative changes in the temporomandibular joint (TMJ) associated with aging can affect mandibular shape and reduce growth potential when stimulated by functional appliance therapy. This study was designed to evaluate the morphological changes in the mandibles of male mice associated with aging and biomechanical stimulus. Every 3 days over the course of 1 month, the lower incisors were trimmed by 1 mm to induce mandibular advancement (MA) when the animal was feeding. The left mandibles of the 23 experimental and 27 control animals were subsequently dissected, and digital images were obtained to analyze nine linear/angular measurements. Because mandibular morphology depends on the maintenance of condylar cartilage, the surfaces of the condylar cartilage and the ascending ramus of the mandible were also analyzed by scanning electron microscopy (SEM). The linear measurements of the mandible showed changes according to age in the control group and a growth response in the mandibular condyle in 7-and 15-month-old mice after MA. Moreover, SEM analysis revealed depressions in the anterior region of the condylar cartilage and inclined vascular grooves in the ascending ramus in the 7-and 15-month-old experimental mice. Although the growth potential is reduced in mice after 6 months of age, the results showed that continuous growth of the mandible occurs after maturation, except in the condyle, and that biomechanical stimulus of the TMJ of male mice leads to condylar growth. These results suggest that mature and old individuals can favorably respond to maxillary functional orthopedic therapy.

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Section: Discussionsupporting

confidence: 88%

Section: Discussionmentioning

confidence: 95%

mentioning

confidence: 99%

mentioning

confidence: 99%

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Morphological Changes in the Mandible of Male Mice Associated With Aging and Biomechanical Stimulus

Tagliaro

Oliveira

Padilha

et al. 2009

The Anatomical Record

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“…This study has shown not only age-related but also stress-related changes in the morphological characteristics of the mandible. Many studies have been published regarding the morphological changes of the mandible during normal development (Bodner et al, 1998;Franchi et al, 2001;Lee et al, 2001;Ramaesh and Bard, 2003;Radlanski et al, 2003;Monteiro and Reis, 2005;Tagliaro et al, 2006Tagliaro et al, , 2009Pessa et al, 2008;Leamy et al, 2008). However, it remains unclear how to precisely detect abnormal morphology.…”

Section: Discussionmentioning

confidence: 99%

Mathematical Analysis of Mandibular Morphogenesis by Micro‐CT‐Based Mouse and Alizarin Red S‐Stained‐Based Human Studies During Development

Rafiq

Udagawa

Lundh

et al. 2011

The Anatomical Record

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Prenatal development of the mandible is an important factor in its postnatal function. To examine quantitatively normal and abnormal developmental changes of the mandible, we here evaluated morphological changes in mineralizing mandibles by thin-plate spline (TPS) including bending energy (BE) and Procrustes distance (PD), and by Procrustes analyses including warp analysis, regression analysis, and discriminant function analysis. BE and PD were calculated from lateral views of the mandibles of mice or of human fetuses using scanned micro-computed tomography (CT) images or alizarin red S-stained specimens, respectively. BE and PD were compared (1) between different developmental stages, and further, to detect abnormalities in the data sets and to evaluate the deviation from normal development in mouse fetuses, (2) at embryonic day (E) 18.5 between the normal and deformed mandibles, the latter being caused by suturing the jaw at E15.5, (3) at E15.5 and E18.5 between normal and knockout mutant mice of receptor tyrosine kinaselike orphan receptor (Ror) 2. In mice, BE and PD were large during the prenatal period and small after postnatal day 3, suggesting that the mandibular shape changes rapidly during the prenatal and early postnatal periods. In humans, BE of the mandibles peaked at 16-19 weeks of gestation, suggesting the time-dependent change in the mandibular shape. TPS and Procrustes analyses statistically separated the abnormal mandibles of the sutured or Ror2 mutant mouse fetuses from the normal mandible. These results suggest that TPS and Procrustes analyses are useful for assessing the morphogenesis and deformity of the mandible. Anat Rec, 295:313-327, 2012 The mammalian mandible is a complex morphological structure formed by various morphogenetic components of different embryological origins. These morphogenetic components were assembled during development to form the final structure (Atchley, 1993). The mandible originates from cells of the neural crest that migrate to the first mandibular arch and form the embryonic mesenchyme, which later develops into skeletal, dental, and connective tissues. The mesenchymal cells aggregate and produce condensations before undergoing differentiation to produce the morphogenetic components of the mandible (Atchley and Hall, 1991). The mandible consists of two symmetrical halves (right and left), each formed by a dentary bone with four morphogenetic regions: the mandibular body (ramus) and three processes (coronoid, condylar, and angular).Establishing normative expectations for experimentally induced changes in size and shape will be an important innovation in three-dimensional (3-D) micro-computed tomography (CT)-based morphological assessments, especially in quantifying differences in the values of those parameters between sets of developing mandibles as a primary aim. Nondestructive methods such as micro-magnetic resonance imaging (Pieles et al., 2007) and micro-CT (Johnson et al., 2006;Boughner et al., 2008;Nagase et al., 2008;Parsons et al., 2008;Hallgrimss...

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Deferoxamine mesylate enhances mandibular advancement‐induced condylar osteogenesis by promoting H‐type angiogenesis

2023

J of Oral Rehabilitation

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Class II malocclusion manifested by mandibular deficiency destroys the facial attractiveness. 1 Promoting mandibular growth through functional orthopaedic treatments, such as mandibular advancement (MA)-induced condylar remodelling, has been shown to be effective in improving facial aesthetics. 2 However, the effect of MA-induced condylar osteogenesis varies from person to person. 3 Especially in non-growing patients, the effect of MA-induced condylar osteogenesis is still controversial. 4 Therefore, constructing

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Mandibular advancement and morphological changes in the mandibles of female mice of different ages

Cited by 6 publications

References 27 publications

Morphological Changes in the Mandible of Male Mice Associated With Aging and Biomechanical Stimulus

Morphological Changes in the Mandible of Male Mice Associated With Aging and Biomechanical Stimulus

Mathematical Analysis of Mandibular Morphogenesis by Micro‐CT‐Based Mouse and Alizarin Red S‐Stained‐Based Human Studies During Development

Deferoxamine mesylate enhances mandibular advancement‐induced condylar osteogenesis by promoting H‐type angiogenesis

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