Integral indicator of bone quality is microhardness, which depends both on the condition of the inorganic component and the quality of the extracellular organic matrix. There are a lot of researches indicated microhardness changes around the metal implants, but it is not clear how it change distant from injured place.The aim of our research was to determine the microhardness of the femoral bone at different terms after the implantation of metal alloys with different composition.65 rabbits were random in 5 groups -intact, control (bone defect) and 3 experimental. We used TiVT6 alloy with high elasticity module and β-(Ti-Zr) alloy with low Young module for the experimental groups. All alloys were implanted in distal epiphysis of femur.Bone microhardness was detected in periimplanted zone as well as in middle of diaphysis and proximal epiphysis.Injury of bone leads to a decrease in the hardness in the zone of the defec as well as in distal zones, followed by recovery up to 6 month. Use the classic high-modulus alloy TiVT6 leads to a significant decrease in the microhardness of all sections of bone in the early and late postoperative period. Implantation of low modulus alloy β (Ti-Zr) leads to a reduction of hardness just after 1 and 3 months after the injury, and the use of hydroxyapatite coating significantly reduces the loss of bone quality at all times after implantation.