Mandibular condylar hyperplasia and its correlation with vascular endothelial growth factor

Abstract

Condylar hyperplasia (CH) is a rare condition most commonly characterised by excessive unilateral growth of the mandibular condyle after cessation of growth on the contralateral side. 1 The aetiology has yet to be determined, but many theories include trauma, metabolic and endocrine disturbances and genetic predilection. [2][3][4][5][6][7][8][9][10] There are some reports in the literature of a greater prevalence in females, but other authors propose this discrepancy is caused by differences between the genders in willingness to seek treatment. [11][12][13] Clinical presentation most often begins in the second and third decades, which becomes more evident when the affected side continues growing following contralateral cessation. 14 CH represents the most common temporomandibular joint growth abnormality in the postnatal period, with neither side appearing to be preferred. 15 Clinically, the condition leads to facial asymmetry. The affected side is most commonly described as having 'fullness of face,' while the unaffected contralateral side may appear flattened. 16

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