Mandibular Distraction Using Bone Morphogenic Protein and Rapid Distraction in Neonates With Pierre Robin Syndrome

Abstract

Rapid protocol distraction with rhBMP-2 allows distraction of the hypoplastic mandible to class III occlusion during the initial operation and avoids the latency and distraction phases of standard mandibular distraction. This case series demonstrates the safety and effectiveness of rapid distraction in neonates with Pierre Robin syndrome. Larger studies and long-term follow-up are necessary; however, this study suggests that rapid protocol distraction with rhBMP-2 is effective in neonates with Pierre Robin syndrome.

Robin Sequence: From Diagnosis to Development of an Effective Management Plan

“…82 Although results from small series of infants with RS who have successfully undergone MDO for airway obstruction in infancy exist, data from large studies analyzing outcomes have not been reported to date. 66,78,81,83,84 Although MDO is an attractive surgical option for achieving rapid resolution of airway obstruction, as with any procedure, potential risks must be considered (Table 2).…”

Clinical Efficacy of Growth Factors to Enhance Tissue Repair in Oral and Maxillofacial Reconstruction: A Systematic Review

“…Other clinical applications for BMPs have been reported for periodontal repair, craniofacial defects, distraction osteogenesis in Pierre‐Robin cases and bisphosphonate related necrosis of the jaws (BRONJ) . Only periodontal repair has been evaluated in two RCTs using 500 μg of GDF‐5 /g TCP in the treatment of intrabony pockets.…”

“…augm. 185-191 195,197,200,201 206,210 Segmental reconstruction 213 238 Craniofacial defects 237 150 mg/ml) and thus did not allow for evaluation of rhPDGF-BB alone. The controlled study 178 had compared three dosage levels (500 mg, 1000 mg and 1500 mg/ ml), with DFDBA as carrier, however, the growth factor free controls had received a different biomaterial (bovine bine mineral) and a collagen membrane.…”

A clinical narrative review of mandibular distraction osteogenesis in neonates with Pierre Robin sequence

“…Some studies are establishing the safety and effectiveness of rapid distraction protocols and shorter consolidation phase by applying recombinant human bone morphogenetic protein to the bony regenerate, which is well known to hasten bone healing in fractures [41,42]. Such studies are clinically important since shortening the distraction and/or the consolidation phase may reduce the morbidity and cost associated with distraction osteogenesis.…”