Mandibular metastasis of cholangiocarcinoma: A case report

Abstract

Tumors metastasizing from distant regions to the oral and maxillofacial region are uncommon, comprising only 1%-2% of all malignancies. Cholangiocarcinoma is a malignancy that arises from cholangiocytes, which are epithelial cells that line the bile ducts. These cancers are difficult to diagnose and have a poor prognosis. In this paper, we report a rare case of mandibular metastasis of cholangiocarcinoma diagnosed at the primary site and discuss the radiographic findings observed in this case.

Mandibular metastasis of primary extrahepatic biliary carcinoma: Case report

“…The oral cavity is a very uncommon site of metastasis and is usually evidence of a disseminated disease, which real incidence is difficult to determine precisely because an unknown number of patients die without investigating oral metastasis. The known cases of maxillofacial metastases involve only patients who have had symptoms in this region during their lifetime [1] .…”

“…Cholangiocarcinoma (CCA) is an uncommon and aggressive adenocarcinoma originating from cholangiocytes, which are epithelial cells that line the bile ducts, thus constituting a heterogeneous group of malignant diseases that can appear anywhere in the biliary tree [1] , [2] , [3] . The CCA is the second most common hepatic malignancy after hepatocellular carcinoma (HCC) [4] .…”

“…The CCA is the second most common hepatic malignancy after hepatocellular carcinoma (HCC) [4] . This condition is difficult to diagnose and has an unfavorable prognosis, with survival lower than 5 % of cases in five years due to the tendency to insidious progression [1] .…”

“…Considering that metastatic CCAs in the mandible are rare because the spread to other vital organs before the mandible can result in a low survival rate [1] , the present report addresses the case of a young patient with mandibular metastasis of an extrahepatic bile duct carcinoma, treated in a public Hospital in Brazil. As far as we know, this is the only report in the literature of a case like this.…”

Perfil Epidemiológico Das Fissuras Orofaciais No Brasil

“…Para o tratamento e prognóstico dos TMSE são considerados o sítio de origem do tumor primário e o grau de disseminação metastática. O tratamento dos TMSE pode envolver ressecção cirúrgica, radiação, quimioterapia ou a combinação dessas modalidades terapêuticas (ÁLVAREZ-ÁLVAREZ et al, 2006;GOMES et al, 2009;BEENA et al, 2011;MOSER et al, 2011;POULIAS, MELAKOPOULOS, TOSIOS, 2011;JAIN et al, 2013;MISIR, MERCAN, GÜNHAN, 2013;DHUPAR et al, 2014;LAKSHMI et al, 2014;VARGHESE, SINGH, SREELA, 2014;YOU et al, 2015).…”