Reconstructing maxillofacial defects is challenging due to its complex anatomy and cosmetic and functional effects on patients. From a functional and esthetic view, it is imperative for surgeons to accurately restore the defect in a way that will ensure patient satisfaction and well-being. Here, a case of large lytic lesion of anterior mandible, causing extensive bony resorption, in a young female patient is reported. Incisional biopsy was performed and the histopathological features were suggestive of Central giant cell granuloma (CGCG). Surgical treatment by en-bloc resection of the lesion was done. Although, several reconstruction options in the literature are available for the residual bony defect including iliac crest graft, costochondral graft, submental island flaps and more. However, the advent of additive manufacturing, 3–dimensional (3D) printing, and the recent advances in those technologies has positively influenced the biomedical field, leading to the utilization of patient-specific implants (PSIs) in the surgical repair of maxillofacial defects. This report highlights the advantages of using Patient Specific Implant and describes our experience with it.