Mandibular reconstruction: meta‐analysis of iliac‐ versus fibula‐free flaps

Lonie, Sarah; Herle, Pradyumna; Paddle, Alenka; Pradhan, Neelprada; Birch, Theo; Shayan, Ramin

doi:10.1111/ans.13274

Cited by 86 publications

(70 citation statements)

References 45 publications

(41 reference statements)

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“…We preferred the use of the vascularized iliac crest flap. There are no significant differences in terms of morbidity of the donor site between iliac crest and fibula free flaps patients [17]. All patients of the present series experienced pain at the donor site, which lasted for a mean time of 1.7 months; nevertheless, a follow-up of more than 6 months showed no residual donor site morbidities.…”

Section: Discussionmentioning

confidence: 49%

The effect of admission to intensive care unit on outcomes and complication rates after head and neck reconstruction

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Chuchueva

et al. 2018

Opuholi golovy i šei

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The study objectiveis to evaluate the utilisation and effectiveness of intensive care unit (ICU) in the postoperative period as to its potential benefits to the head and neck reconstruction services.Materials and methods. This is a retrospective study on 143 consecutive patients who underwent 144 major head and neck microvascular reconstructive procedures performed by a single surgeon, that focused on perioperative management and on the relation between admission to ICU and complications/outcomes.Results.Thirty-four (23.6 %) patients were admitted to ICU during the early postoperative period. Admission to ICU was not associated with lower incidence of complications compared to direct admission to the Head and Neck ward: 29.4 % vs 27.3 % (p = 0.807709).Conclusion.Routinely early postoperative admission to ICU seems not to improve outcomes and/or reduce complications, and, as a consequence, ICU admission should be restricted to selected patients only.

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Section: Discussionmentioning

confidence: 49%

The effect of admission to intensive care unit on outcomes and complication rates after head and neck reconstruction

Carta

Figus

Chuchueva

et al. 2018

Opuholi golovy i šei

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“…However, despite its merits, harvesting and contouring of the fibula demands tremendous skill and expertise. Furthermore, post-operative facial symmetry is an important aesthetic aspect, which is very difficult to achieve (67). Previous studies have reported that harvesting the fibula increases the risk of donor-site morbidity, and lowers walking endurance in the short-term and decrease the ability to do strenuous activity in the long-term (68,69).…”

Section: Discussionmentioning

confidence: 99%

Application of additive manufacturing in customized titanium mandibular implants for patients with oral tumors

Xia

Feng

et al. 2020

Oncol Lett

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“…All blood samples were consistently processed and managed as described in specific protocols, no tissue biopsies needed to be the retromolar area of the mandible [9]. Based on current insights from clinical human studies, bone grafts from the iliac crest are suitable for the reconstruction of large defects and atrophic edentulous alveolar crests in the mandible and maxilla [10][11][12]. Despite the still widespread use of iliac bone grafts for reconstructive surgery in dentistry, harvestingespecially from the anterior part of the iliac crest-partially leads to a prolonged operating time as well as to major complications and donor site morbidity, including extended healing periods, chronic donor site pain, functional impairment, wound dehiscence, and deep infections [9,[13][14][15][16][17].…”

Section: Study Design and Participantsmentioning

confidence: 99%

Characterization of circulating DNA in plasma of patients after allogeneic bone grafting

et al. 2019

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Objectives Cell-free DNA (cfDNA) harboring mutations has been found in patients with diseases. Experimental studies have shown that cfDNA can be transmitted, leading to transformations in the host. In the present study, we evaluated whether bone allograft material contains cfDNA and whether this foreign cfDNA can be released into the patient's blood circulation. Materials and methods Plasma samples were collected preoperatively and postoperatively on the same day, at 5 weeks, and 4 months from 25 women who received bone allograft material (test group) from male donors and from 10 women who were treated with autologous graft (control group, only per-and postoperative samples were collected). DNA was quantified and characterized in bone material and plasma samples by quantitative PCR with primers specific for glyceraldehyde-3-phosphate dehydrogenase (GAPDH) and Y chromosome and gel electrophoresis. DNA in bone material was digested by different concentrations of DNase I. Results We detected between 1 and 1.8 μg cfDNA fragments at a length around 601 base pairs (bp) and smaller in each 100 mg allograft. Treatment of the allograft with DNase I completely degraded the longer but not the shorter DNA 90-bp fragments. Y-DNA was not detected in the patients' bloodstream at any time during the treatment and follow-up, but elevated levels of circulating cfDNA could be measured immediately postoperatively. Conclusions Our results suggest that a transmission of DNA from allografts used for alveolar ridge reconstruction in humans is unlikely. The observed increase in circulating cfDNA in allograft and autograft patients immediately postoperatively may be elicited by the surgical procedure. Clinical relevance The results support the safety of allograft materials. The results suggest that human allograft materials seem not to release DNA into the blood since we did not measure Y-DNA with our technique.

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Mandibular reconstruction: meta‐analysis of iliac‐ versus fibula‐free flaps

Cited by 86 publications

References 45 publications

The effect of admission to intensive care unit on outcomes and complication rates after head and neck reconstruction

The effect of admission to intensive care unit on outcomes and complication rates after head and neck reconstruction

Application of additive manufacturing in customized titanium mandibular implants for patients with oral tumors

Characterization of circulating DNA in plasma of patients after allogeneic bone grafting

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